STRINGSTRING
AKT3 AKT3 CR201_G0053435 CR201_G0053435 CR201_G0036525 CR201_G0036525 CUL5 CUL5 ERBB3 ERBB3 RNF41 RNF41 UBC UBC HSP90AA1 HSP90AA1 AKT1 AKT1 USP8 USP8 NRG4 NRG4 CR201_G0003353 CR201_G0003353 STUB1 STUB1 ENSPPYP00000008172 ENSPPYP00000008172 ERBB2 ERBB2 ENSPPYP00000009931 ENSPPYP00000009931 MATK MATK CDC37 CDC37 UBA52 UBA52 AKT2 AKT2 ERBB4 ERBB4 PTPN18 PTPN18 EREG EREG BTC BTC EGF EGF ENSPPYP00000016980 ENSPPYP00000016980 ENSPPYP00000017056 ENSPPYP00000017056 ENSPPYP00000017062 ENSPPYP00000017062 NRG2 NRG2 HBEGF HBEGF EGFR EGFR PTPN12 PTPN12 NRG1 NRG1 ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 ERBIN ERBIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CR201_G0053435UBB isoform 1. (128 aa)
CR201_G0036525NRG3 isoform 1. (396 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (732 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. (1342 aa)
RNF41E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa)
UBCUBC isoform 2. (625 aa)
HSP90AA1HSP90AA1 isoform 6. (615 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
USP8USP8 isoform 3; Belongs to the peptidase C19 family. (1118 aa)
NRG4NRG4 isoform 5. (115 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ENSPPYP00000008172annotation not available (229 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
ENSPPYP00000009931annotation not available (76 aa)
MATKTyrosine-protein kinase. (474 aa)
CDC37CDC37 isoform 2. (338 aa)
UBA52UBA52 isoform 10. (128 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERBB4Receptor protein-tyrosine kinase. (1284 aa)
PTPN18PTPN18 isoform 2. (460 aa)
EREGEREG isoform 1. (169 aa)
BTCBTC isoform 1. (178 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1177 aa)
ENSPPYP00000016980annotation not available (100 aa)
ENSPPYP00000017056annotation not available (412 aa)
ENSPPYP00000017062annotation not available (62 aa)
NRG2NRG2 isoform 2. (448 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (750 aa)
NRG1NRG1 isoform 10. (692 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
ERBINErbb2 interacting protein. (1419 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.