STRINGSTRING
AKT3 AKT3 PSMB4 PSMB4 PSMB2 PSMB2 OTUD3 OTUD3 CR201_G0053435 CR201_G0053435 PTEN PTEN ENSPPYP00000003414 ENSPPYP00000003414 PSMA5 PSMA5 PSMD3 PSMD3 PSMD4 PSMD4 TRIM27 TRIM27 PSMA6 PSMA6 PSMC1 PSMC1 LOC100457600 LOC100457600 ENSPPYP00000023569 ENSPPYP00000023569 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023561 ENSPPYP00000023561 PSMD7 PSMD7 PSMB1-2 PSMB1-2 PSMC3 PSMC3 PSMA1 PSMA1 RNF141 RNF141 ENSPPYP00000004744 ENSPPYP00000004744 PSMD9 PSMD9 UBC UBC PSMB5 PSMB5 PSMB11 PSMB11 PSME1 PSME1 PSME2 PSME2 PSMC6 PSMC6 PSMA3 PSMA3 AKT1 AKT1 MKRN3 MKRN3 NEDD4 NEDD4 PSMA4 PSMA4 CR201_G0003353 CR201_G0003353 STUB1 STUB1 CSNK2A2 CSNK2A2 PSMB10 PSMB10 WWP2 WWP2 PSMB6 PSMB6 ENSPPYP00000008980 ENSPPYP00000008980 PSMD11 PSMD11 PSME3 PSME3 PSMB3 PSMB3 PSMC5 PSMC5 PSMD12 PSMD12 PSMA8 PSMA8 UBA52 UBA52 PSMD8 PSMD8 PSMC4 PSMC4 AKT2 AKT2 PSMF1 PSMF1 CSNK2A1 CSNK2A1 PSMA7 PSMA7 PSME4 PSME4 PSMD14 PSMD14 PSMD1 PSMD1 MKRN2 MKRN2 USP13 USP13 PSMD6 PSMD6 PSMD2 PSMD2 GUF1 GUF1 OTUD4 OTUD4 CSNK2B CSNK2B FRK FRK RNF146 RNF146 PSMB1 PSMB1 PSMB8 PSMB8 PSMB9 PSMB9 PSMA2 PSMA2 ENSPPYP00000019816 ENSPPYP00000019816 PSMC2 PSMC2 MKRN1 MKRN1 TNKS TNKS PREX2 PREX2 PSMD5 PSMD5 PSMB7 PSMB7 TRIM7 TRIM7 PSMD13 PSMD13 ENSPPYP00000022487 ENSPPYP00000022487 CR201_G0022864 CR201_G0022864 PSMD10 PSMD10 XIAP XIAP ENSPPYP00000023500 ENSPPYP00000023500
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMB2Proteasome subunit beta. (201 aa)
OTUD3OTUD3 isoform 1. (408 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSPPYP00000003414annotation not available (440 aa)
PSMA5Proteasome subunit alpha type. (278 aa)
PSMD3PSMD3 isoform 1. (536 aa)
PSMD4PSMD4 isoform 1. (384 aa)
TRIM27Tripartite motif containing 27. (513 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
ENSPPYP00000023569annotation not available (247 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023561annotation not available (122 aa)
PSMD7PSMD7 isoform 1. (324 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
RNF141RING finger protein 141; May be involved in spermatogenesis. (229 aa)
ENSPPYP00000004744annotation not available (440 aa)
PSMD9PSMD9 isoform 1. (223 aa)
UBCUBC isoform 2. (625 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
MKRN3Makorin ring finger protein 3. (507 aa)
NEDD4E3 ubiquitin-protein ligase. (937 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CSNK2A2CSNK2A2 isoform 1; Belongs to the protein kinase superfamily. (327 aa)
PSMB10Proteasome subunit beta. (256 aa)
WWP2E3 ubiquitin-protein ligase. (874 aa)
PSMB6Proteasome subunit beta. (239 aa)
ENSPPYP00000008980annotation not available (158 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
PSMB3Proteasome subunit beta. (218 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
UBA52UBA52 isoform 10. (128 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
CSNK2A1CSNK2A1 isoform 1; Belongs to the protein kinase superfamily. (391 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (831 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (673 aa)
OTUD4OTUD4 isoform 1. (1115 aa)
CSNK2BCasein kinase II subunit beta. (215 aa)
FRKTyrosine-protein kinase. (505 aa)
RNF146E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (355 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMB9Proteasome subunit beta. (218 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ENSPPYP00000019816annotation not available (197 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
MKRN1Makorin ring finger protein 1. (418 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
PREX2PREX2 isoform 1. (1591 aa)
PSMD5PSMD5 isoform 8. (97 aa)
PSMB7Proteasome subunit beta. (277 aa)
TRIM7TRIM7 isoform 2. (357 aa)
PSMD13PSMD13 isoform 6. (376 aa)
ENSPPYP00000022487annotation not available (153 aa)
CR201_G0022864MKRN1 isoform 4. (480 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
XIAPXIAP isoform 2. (513 aa)
ENSPPYP00000023500annotation not available (140 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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