STRINGSTRING
RIPK1 RIPK1 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 IKBKG IKBKG UBE2NL UBE2NL TLR4 TLR4 LY96 LY96 IKBKB IKBKB CD14 CD14 ENSPPYP00000012086 ENSPPYP00000012086 SARM1 SARM1 CR201_G0003353 CR201_G0003353 RIPK3 RIPK3 UBC UBC UBE2N UBE2N BIRC2 BIRC2 TRAF6 TRAF6 CHUK CHUK CR201_G0053435 CR201_G0053435
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
TLR4TLR4 isoform 1; Belongs to the Toll-like receptor family. (804 aa)
LY96Lymphocyte antigen 96. (160 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (343 aa)
ENSPPYP00000012086annotation not available (110 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
UBCUBC isoform 2. (625 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
BIRC2Baculoviral IAP repeat containing 2. (597 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
CHUKCHUK isoform 1. (746 aa)
CR201_G0053435UBB isoform 1. (128 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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