STRINGSTRING
CR201_G0036895 CR201_G0036895 DYNC1I1 DYNC1I1 CFTR CFTR HSF1 HSF1 VCP VCP TUBB4B TUBB4B LOC100434822 LOC100434822 ENSPPYP00000022418 ENSPPYP00000022418 ENSPPYP00000022487 ENSPPYP00000022487 HDAC6 HDAC6 UBE2NL UBE2NL CR201_G0054189-2 CR201_G0054189-2 ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023866 ENSPPYP00000023866 TUBA8 TUBA8 TUBA1C TUBA1C TUBA1B TUBA1B TUBB2B TUBB2B CETN3 CETN3 ENSPPYP00000017062 ENSPPYP00000017062 ENSPPYP00000017056 ENSPPYP00000017056 ENSPPYP00000016980 ENSPPYP00000016980 DYNC1LI1 DYNC1LI1 ARL13B ARL13B ENSPPYP00000014962 ENSPPYP00000014962 TUBA4A TUBA4A DYNC1I2 DYNC1I2 ENSPPYP00000013420 ENSPPYP00000013420 PCNT PCNT TUBB1 TUBB1 TMEM189-UBE2V1 TMEM189-UBE2V1 ENSPPYP00000012086 ENSPPYP00000012086 ENSPPYP00000011873 ENSPPYP00000011873 UBA52 UBA52 CETN1 CETN1 TUBB6 TUBB6 ENSPPYP00000009931 ENSPPYP00000009931 DYNLL2 DYNLL2 ENSPPYP00000008980 ENSPPYP00000008980 TUBB3 TUBB3 DYNC1LI2 DYNC1LI2 CR201_G0003353 CR201_G0003353 HSP90AA1 HSP90AA1 IFT88 IFT88 ENSPPYP00000005898 ENSPPYP00000005898 UBC UBC DYNLL1 DYNLL1 UBE2N UBE2N ENSPPYP00000004309 ENSPPYP00000004309 TUBAL3 TUBAL3 CR201_G0054189 CR201_G0054189 PARK7 PARK7 CR201_G0053435 CR201_G0053435 ENSPPYP00000000154 ENSPPYP00000000154 LOC100452886 LOC100452886 TUBE1 TUBE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CR201_G0036895PRKN isoform 8. (335 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
HSF1HSF1 isoform 2. (594 aa)
VCPTransitional endoplasmic reticulum ATPase isoform X1. (806 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (388 aa)
LOC100434822TUBA3C isoform 1. (450 aa)
ENSPPYP00000022418annotation not available (435 aa)
ENSPPYP00000022487annotation not available (153 aa)
HDAC6HDAC6 isoform 2. (1208 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
CR201_G0054189-2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023866annotation not available (88 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (476 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
CETN3CETN3 isoform 1. (167 aa)
ENSPPYP00000017062annotation not available (62 aa)
ENSPPYP00000017056annotation not available (412 aa)
ENSPPYP00000016980annotation not available (100 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
ARL13BARL13B isoform 4. (428 aa)
ENSPPYP00000014962annotation not available (447 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
DYNC1I2Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and help dynein bind to dynactin 150 kDa component (By similarity). organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such a [...] (638 aa)
ENSPPYP00000013420annotation not available (154 aa)
PCNTPCNT isoform 1. (3265 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
ENSPPYP00000012086annotation not available (110 aa)
ENSPPYP00000011873annotation not available (417 aa)
UBA52UBA52 isoform 10. (128 aa)
CETN1CETN1 isoform 1. (172 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
ENSPPYP00000009931annotation not available (76 aa)
DYNLL2Dynein light chain. (89 aa)
ENSPPYP00000008980annotation not available (158 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
DYNC1LI2Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (465 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
HSP90AA1HSP90AA1 isoform 6. (615 aa)
IFT88IFT88 isoform 2. (768 aa)
ENSPPYP00000005898annotation not available (382 aa)
UBCUBC isoform 2. (625 aa)
DYNLL1Dynein light chain. (89 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
ENSPPYP00000004309annotation not available (437 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
CR201_G0054189Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
PARK7PARK7 isoform 1. (189 aa)
CR201_G0053435UBB isoform 1. (128 aa)
ENSPPYP00000000154annotation not available (424 aa)
LOC100452886TUBB8 isoform 7. (440 aa)
TUBE1Tubulin epsilon 1; Belongs to the tubulin family. (475 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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