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| | CSNK2B | Casein kinase II subunit beta. (215 aa) |
| | ENSPPYP00000018466 | Cytochrome c-like. (105 aa) |
| | LRPPRC | LRPPRC isoform 5. (803 aa) |
| | COX4I2 | Cytochrome c oxidase subunit 4I2. (171 aa) |
| | PSMA5 | Proteasome subunit alpha type. (278 aa) |
| | PSMD3 | PSMD3 isoform 1. (536 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa) |
| | COX6B1 | Cytochrome c oxidase subunit 6B1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and [...] (50 aa) |
| | UBA52 | UBA52 isoform 10. (128 aa) |
| | SIN3B | SIN3B isoform 1. (1118 aa) |
| | TRIR | Telomerase RNA component interacting RNase. (176 aa) |
| | CARM1 | CARM1 isoform 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (522 aa) |
| | KEAP1 | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa) |
| | STAP2 | STAP2 isoform 4. (391 aa) |
| | PSMA8 | Proteasome subunit alpha type. (256 aa) |
| | CR201_G0002531 | TXNDC2 isoform 4. (478 aa) |
| | ENSPPYP00000010045 | annotation not available (622 aa) |
| | NFE2L1 | Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...] (788 aa) |
| | ENSPPYP00000009931 | annotation not available (76 aa) |
| | MAFG | MAF bZIP transcription factor G. (162 aa) |
| | P4HB | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (508 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa) |
| | PSMC5 | PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa) |
| | TACO1 | TACO1 isoform 1. (293 aa) |
| | PSMB3 | Proteasome subunit beta. (218 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] (1586 aa) |
| | STAT3 | Signal transducer and activator of transcription. (772 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa) |
| | COX11 | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. (287 aa) |
| | COIL | COIL isoform 1. (511 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | NCOR1 | NCOR1 isoform 1. (2467 aa) |
| | ENSPPYP00000008980 | annotation not available (158 aa) |
| | SCO1 | SCO cytochrome c oxidase assembly protein 1. (301 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | COX6A2 | Cytochrome c oxidase subunit 6A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] (97 aa) |
| | ENSPPYP00000008618 | annotation not available (118 aa) |
| | MAP1LC3B | MAP1LC3B isoform 1. (129 aa) |
| | DKFZp459N0929 | COX4I1 isoform 1. (116 aa) |
| | NQO1 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis; Belongs to the NAD(P)H dehydrogenase (quinone) family. (274 aa) |
| | PSMB10 | Proteasome subunit beta. (256 aa) |
| | CSNK2A2 | CSNK2A2 isoform 1; Belongs to the protein kinase superfamily. (327 aa) |
| | CHD9 | CHD9 isoform 1. (2898 aa) |
| | ENSPPYP00000024510 | annotation not available (85 aa) |
| | PSMD4 | PSMD4 isoform 1. (384 aa) |
| | ATOX1 | Antioxidant 1 copper chaperone. (68 aa) |
| | PSMA6 | Proteasome endopeptidase complex. (167 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | PRDX2 | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (198 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1464 aa) |
| | NPLOC4 | NPLOC4 isoform 1. (609 aa) |
| | LOC100457600 | Proteasome subunit beta type-5-like. (263 aa) |
| | DESI1 | DESI1 isoform 1. (242 aa) |
| | CR201_G0036777 | COX4I1 isoform 7. (91 aa) |
| | MTFP1 | Mitochondrial fission process protein 1 isoform X1. (149 aa) |
| | ENSPPYP00000023569 | annotation not available (247 aa) |
| | ENSPPYP00000023562 | annotation not available (156 aa) |
| | ENSPPYP00000023561 | annotation not available (122 aa) |
| | PSMD7 | PSMD7 isoform 1. (324 aa) |
| | GPX1 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa) |
| | TKT | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (580 aa) |
| | PSMB1-2 | Proteasome subunit beta type-1. (241 aa) |
| | ENSPPYP00000023500 | annotation not available (140 aa) |
| | COX3 | Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa) |
| | COX2 | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa) |
| | COX1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa) |
| | G6PD | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (543 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | ATP7A | ATPase copper transporting alpha. (1500 aa) |
| | COX7B | Cytochrome c oxidase subunit 7B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (80 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1136 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | TBL1X | TBL1X isoform 1. (587 aa) |
| | ENSPPYP00000022487 | annotation not available (153 aa) |
| | PSMD13 | PSMD13 isoform 6. (376 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | ENSPPYP00000022312 | annotation not available (75 aa) |
| | NOTCH1 | NOTCH1 isoform 1. (2107 aa) |
| | RXRA | RXRA isoform 2. (456 aa) |
| | SURF1 | SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. (305 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | PSMD5 | PSMD5 isoform 8. (97 aa) |
| | TXNDC8 | TXNDC8 isoform 3. (115 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (220 aa) |
| | ENSPPYP00000021735 | Cytochrome c-like. (38 aa) |
| | NUDT2 | Nudix hydrolase 2. (147 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | MYC | MYC isoform 1. (453 aa) |
| | COX6C | COX6C isoform 10. (75 aa) |
| | TGS1 | Trimethylguanosine synthase 1. (853 aa) |
| | GSR | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (472 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) |
| | NDUFA4 | NDUFA4 isoform 1. (81 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | NPVF | Neuropeptide VF precursor. (196 aa) |
| | NFE2L3 | Nuclear factor, erythroid 2 like 3. (694 aa) |
| | ENSPPYP00000019816 | annotation not available (197 aa) |
| | NME8 | NME8 isoform 1. (588 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | BLVRA | Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. (296 aa) |
| | NCF1 | NCF1 isoform 3. (364 aa) |
| | MAFK | MAF bZIP transcription factor K. (156 aa) |
| | COX19 | Cytochrome c oxidase assembly factor COX19. (90 aa) |
| | PSMB9 | Proteasome subunit beta. (218 aa) |
| | PSMB8 | Proteasome subunit beta. (272 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | SOD2 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (158 aa) |
| | LOC100436899 | Cytochrome c oxidase assembly protein COX11, mitochondrial-like. (276 aa) |
| | SESN1 | SESN1 isoform 1. (551 aa) |
| | BACH2 | BACH2 isoform 1. (841 aa) |
| | ME1 | Malic enzyme. (538 aa) |
| | COX7A2 | Cytochrome c oxidase subunit 7A2. (115 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (637 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | BLVRB | BLVRB isoform 1. (207 aa) |
| | COX6B2 | Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa) |
| | COX7A1 | Cytochrome c oxidase subunit 7A1. (79 aa) |
| | CR201_G0053238 | KLHL17 isoform 2. (255 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa) |
| | SRXN1 | Sulfiredoxin-1. (166 aa) |
| | TRIM58 | TRIM58 isoform 1. (486 aa) |
| | COX20 | Cytochrome c oxidase assembly factor COX20. (118 aa) |
| | DESI2 | Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Belongs to the DeSI family. (180 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | C1orf198 | Chromosome 1 open reading frame 198. (327 aa) |
| | NCF2 | NCF2 isoform 3. (526 aa) |
| | PRDX6 | Peroxiredoxin 6. (225 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | TXNIP | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] (391 aa) |
| | LOC100440996 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4. (81 aa) |
| | GCLM | Glutamate-cysteine ligase modifier subunit. (274 aa) |
| | GPX7 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (187 aa) |
| | PRDX1 | PRDX1 isoform 2. (199 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | SESN2 | Sestrin-2; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcripti [...] (480 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (352 aa) |
| | CR201_G0025777 | PGD isoform 7. (404 aa) |
| | CR201_G0053435 | UBB isoform 1. (128 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | DENND10 | FAM45A isoform 2. (405 aa) |
| | PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (256 aa) |
| | TALDO1 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa) |
| | ENSPPYP00000003414 | annotation not available (440 aa) |
| | GSTP1 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (323 aa) |
| | CCS | Copper chaperone for superoxide dismutase. (274 aa) |
| | DPP3 | Dipeptidyl-peptidase III. (737 aa) |
| | PRDX5 | Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (344 aa) |
| | COX8A | T0108974 isoform 1. (69 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa) |
| | ENSPPYP00000003894 | annotation not available (104 aa) |
| | PSMA1 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa) |
| | TRIM21 | TRIM21 isoform 1. (368 aa) |
| | NOX4 | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). (578 aa) |
| | COX14 | Cytochrome c oxidase assembly factor COX14. (57 aa) |
| | CR201_G0001249 | TXNRD1 isoform 17. (277 aa) |
| | LOC103892145 | Cytochrome c oxidase subunit 6A1, mitochondrial. (109 aa) |
| | GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (136 aa) |
| | SPPL3 | SPPL3 isoform 1. (383 aa) |
| | PSMD9 | PSMD9 isoform 1. (223 aa) |
| | NCOR2 | NCOR2 isoform 6. (2461 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | LOC100459812 | COX5A isoform 4. (150 aa) |
| | PSMB5 | Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | ERO1A | ERO1A isoform 1. (467 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (527 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | GPX2 | GPX2 isoform 4. (150 aa) |
| | COX16 | Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family. (85 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | ENSPPYP00000007168 | annotation not available (75 aa) |
| | SPATA5L1 | SPATA5L1 isoform 1. (753 aa) |
| | NOX5 | NOX5 isoform 4. (763 aa) |
| | LOC100461926 | COX5A isoform 1. (150 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | HBM | Hemoglobin subunit mu; Belongs to the globin family. (141 aa) |
| | LOC112128473 | HBA1 isoform 1; Belongs to the globin family. (142 aa) |
| | HBQ1 | HBQ1 isoform 1; Belongs to the globin family. (139 aa) |
| | PDIA2 | Protein disulfide-isomerase A2; Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity); Belongs to the protein disulfide isomerase family. (521 aa) |
| | CREBBP | CREBBP isoform 1. (2328 aa) |
| | HMOX2 | HMOX2 isoform 7. (404 aa) |
| | ABCC1 | ABCC1 isoform 3. (1199 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1186 aa) |
| | AQP8 | AQP8 isoform 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa) |
| | CSNK2A1 | CSNK2A1 isoform 1; Belongs to the protein kinase superfamily. (391 aa) |
| | HM13 | Histocompatibility minor 13. (377 aa) |
| | NCOA6 | NCOA6 isoform 5. (2070 aa) |
| | PSMA7 | Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa) |
| | PTK6 | Tyrosine-protein kinase. (451 aa) |
| | HELZ2 | HELZ2 isoform 3. (2587 aa) |
| | ENSPPYP00000012589 | Putative nuclear receptor corepressor 1-like protein NCOR1P1. (101 aa) |
| | BACH1 | BACH1 isoform 5. (736 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (130 aa) |
| | UFD1 | Ubiquitin recognition factor in ER associated degradation 1. (307 aa) |
| | TXNRD2 | Thioredoxin reductase 2. (522 aa) |
| | HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (288 aa) |
| | CR201_G0024663 | TXN2 isoform 1. (129 aa) |
| | NCF4 | NCF4 isoform 3. (339 aa) |
| | ATF4 | ATF4 isoform 1. (352 aa) |
| | CR201_G0049135 | COX6B1 isoform 4. (108 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | EP300 | EP300 isoform 1. (2380 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (474 aa) |
| | ENSPPYP00000013376 | annotation not available (197 aa) |
| | COX5B | Cytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (181 aa) |
| | FABP1 | Fatty acid binding protein 1. (127 aa) |
| | ENSPPYP00000013663 | annotation not available (38 aa) |
| | PSME4 | Proteasome activator subunit 4. (1843 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1293 aa) |
| | ENSPPYP00000014206 | annotation not available (100 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | NFE2L2 | NFE2L2 isoform 2. (606 aa) |
| | CR201_G0007171 | KIAA2012 isoform 5. (648 aa) |
| | ENSPPYP00000014618 | Uncharacterized protein KIAA2012 homolog. (553 aa) |
| | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa) |
| | CUL3 | CUL3 isoform 1; Belongs to the cullin family. (768 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | TXNRD3 | TXNRD3 isoform 1. (569 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | KLHL18 | KLHL18 isoform 3. (634 aa) |
| | NME9 | NME9 isoform 1; Belongs to the NDK family. (263 aa) |
| | TBL1XR1 | Transducin beta like 1 X-linked receptor 1. (514 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa) |
| | UBXN7 | UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity). (489 aa) |
| | SOD3 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa) |
| | COX7B2 | Cytochrome c oxidase subunit 7B2. (81 aa) |
| | COX18 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). (334 aa) |
| | ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa) |
| | ENSPPYP00000016598 | annotation not available (104 aa) |
| | SPATA5 | SPATA5 isoform 1. (892 aa) |
| | SLC7A11 | Cystine/glutamate transporter; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. (472 aa) |
| | LOC100447051 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa) |
| | SKP2 | SKP2 isoform 1. (410 aa) |
| | GPX8 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (185 aa) |
| | COX7C | COX7C isoform 1. (63 aa) |
| | FBXL17 | FBXL17 isoform 1. (751 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa) |
| | GPX3 | GPX3 isoform 10. (153 aa) |
| | SQSTM1 | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] (436 aa) |
| | GPX5 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa) |
