STRINGSTRING
KCNJ6 KCNJ6 GNG4 GNG4 KCNJ9 KCNJ9 KCNJ10 KCNJ10 GNAI3 GNAI3 GNG5 GNG5 GNG12 GNG12 GNB1 GNB1 ENSPPYP00000002678 ENSPPYP00000002678 GNG3 GNG3 KCNJ5 KCNJ5 GNB3 GNB3 ADCY6 ADCY6 ADCY4 ADCY4 GNG2 GNG2 GNB5 GNB5 ENSPPYP00000007387 ENSPPYP00000007387 GNG13 GNG13 ADCY9 ADCY9 ADCY7 ADCY7 CR201_G0054205 CR201_G0054205 KCNJ16 KCNJ16 KCNJ2 KCNJ2 GNGT2 GNGT2 GNAL GNAL GNG8 GNG8 KCNJ4 KCNJ4 ADCY3 ADCY3 PTRHD1 PTRHD1 KCNJ3 KCNJ3 ADCY5 ADCY5 GPR156 GPR156 GNAI2 GNAI2 ADCY2 ADCY2 CR201_G0042455 CR201_G0042455 GNB2 GNB2 ADCY1 ADCY1 GNG11 GNG11 GNGT1 GNGT1 GNAT3 GNAT3 GNAI1 GNAI1 ADCY8 ADCY8 GABBR2 GABBR2 ENSPPYP00000023095 ENSPPYP00000023095
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ6G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G- protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due t [...] (306 aa)
GNG4Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KCNJ9KCNJ9 isoform 1. (393 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
GNG5Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG12Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (340 aa)
ENSPPYP00000002678annotation not available (281 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KCNJ5KCNJ5 isoform 1. (313 aa)
GNB3G protein subunit beta 3. (340 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
GNG2Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). (71 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (609 aa)
ENSPPYP00000007387annotation not available (61 aa)
GNG13GNG13 isoform 1. (67 aa)
ADCY9ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CR201_G0054205KCNJ12 isoform 1. (420 aa)
KCNJ16KCNJ16 isoform 1. (418 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GNALGNAL isoform 3. (381 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
KCNJ3KCNJ3 isoform 2. (416 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
GPR156GPR156 isoform 1. (813 aa)
GNAI2GNAI2 isoform 1. (303 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
CR201_G0042455GABBR1 isoform 2. (710 aa)
GNB2GNB2 isoform 1. (340 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAT3GNAT3 isoform 1. (355 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GABBR2GABBR2 isoform 2. (934 aa)
ENSPPYP00000023095annotation not available (68 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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