STRINGSTRING
RPE65 RPE65 CYP4A11 CYP4A11 DHRS3 DHRS3 CYP26C1 CYP26C1 CYP26A1 CYP26A1 CYP2C18 CYP2C18 ENSPPYP00000002903 ENSPPYP00000002903 CYP2C8 CYP2C8 RDH5 RDH5 HSD17B6 HSD17B6 RDH16 RDH16 DHRS4 DHRS4 RDH11 RDH11 RDH12 RDH12 CYP1A1 CYP1A1 BCO1 BCO1 RDH8 RDH8 CYP2B6 CYP2B6 CYP2S1 CYP2S1 RETSAT RETSAT CYP26B1 CYP26B1 CYP27C1 CYP27C1 DHRS9 DHRS9 CR201_G0048269 CR201_G0048269 UGT2A3 UGT2A3 UGT2B7 UGT2B7 CR201_G0048259 CR201_G0048259 UGT2B4 UGT2B4 UGT2A1 UGT2A1 ADH5 ADH5 ADH6 ADH6 ADH1A ADH1A ADH7 ADH7 ENSPPYP00000017071 ENSPPYP00000017071 CYP3A5 CYP3A5 CYP3A4 CYP3A4 SDR16C5 SDR16C5 RDH10 RDH10 DGAT1 DGAT1 ALDH1A1 ALDH1A1 PNPLA4 PNPLA4 AWAT2 AWAT2 UGT2B17 UGT2B17 CR201_G0044025 CR201_G0044025 CR201_G0048502 CR201_G0048502 ADH4 ADH4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
CYP4A11CYP4A22 isoform 5; Belongs to the cytochrome P450 family. (519 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
CYP26C1CYP26C1 isoform 2; Belongs to the cytochrome P450 family. (518 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
CYP2C18Cytochrome P450 family 2 subfamily C member 18. (436 aa)
ENSPPYP00000002903Cytochrome P450 family 2 subfamily C polypeptide 9. (401 aa)
CYP2C8CYP2C8 isoform 4; Belongs to the cytochrome P450 family. (490 aa)
RDH511-cis retinol dehydrogenase. (318 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
RDH16RDH16 isoform 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
DHRS4Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). (278 aa)
RDH11Retinol dehydrogenase 11 precursor. (318 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
CYP1A1CYP1A1 isoform 1; Belongs to the cytochrome P450 family. (512 aa)
BCO1BCO1 isoform 1. (547 aa)
RDH8RDH8 isoform 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
CYP2B6CYP2B6 isoform 1; Belongs to the cytochrome P450 family. (491 aa)
CYP2S1CYP2S1 isoform 1; Belongs to the cytochrome P450 family. (563 aa)
RETSATRETSAT isoform 1. (610 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CYP27C1CYP27C1 isoform 1; Belongs to the cytochrome P450 family. (372 aa)
DHRS9DHRS9 isoform 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
CR201_G0048269UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT2A3UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). (527 aa)
UGT2B7UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CR201_G0048259UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
UGT2B4UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
ADH6Alcohol dehydrogenase 6; Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily. (331 aa)
ADH1AAlcohol dehydrogenase 1A. (375 aa)
ADH7ADH7 isoform 2. (387 aa)
ENSPPYP00000017071UDP-glucuronosyltransferase 2B15 isoform X1. (293 aa)
CYP3A5CYP3A43 isoform 5; Belongs to the cytochrome P450 family. (441 aa)
CYP3A4Cytochrome P450 family 3 subfamily A member 4. (503 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
DGAT1O-acyltransferase. (487 aa)
ALDH1A1ALDH1A1 isoform 5; Belongs to the aldehyde dehydrogenase family. (500 aa)
PNPLA4PNPLA4 isoform 1. (253 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
UGT2B17UGT2A3 isoform 2. (301 aa)
CR201_G0044025CYP2B6 isoform 3; Belongs to the cytochrome P450 family. (316 aa)
CR201_G0048502CYP3A7 isoform 2. (503 aa)
ADH4ADH4 isoform 4. (380 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.