STRINGSTRING
AKT3 AKT3 FASLG FASLG MGST3 MGST3 GSTM3 GSTM3 GSTM5 GSTM5 GSTM1 GSTM1 GSTM2 GSTM2 GSTM4 GSTM4 PIK3R3 PIK3R3 CASP9 CASP9 PIK3CD PIK3CD ABCC2 ABCC2 GSTO1 GSTO1 GSTO2 GSTO2 FADD FADD GSTP1 GSTP1 BAD BAD BIRC2 BIRC2 ATM ATM MGST1 MGST1 MDM2 MDM2 APAF1 APAF1 ATP7B ATP7B BAK1 BAK1 MAPK3 MAPK3 TP53 TP53 BRCA1 BRCA1 TOP2A TOP2A ERBB2 ERBB2 BIRC5 BIRC5 PMAIP1 PMAIP1 BCL2 BCL2 AKT2 AKT2 ERCC1 ERCC1 BBC3 BBC3 BCL2L1 BCL2L1 CR201_G0053650 CR201_G0053650 ENSPPYP00000013389 ENSPPYP00000013389 BID-2 BID-2 LOC100461022 LOC100461022 CR201_G0053647 CR201_G0053647 MSH6 MSH6 CASP8 CASP8 MLH1 MLH1 TOP2B TOP2B PIK3CB PIK3CB MGST2 MGST2 CASP3 CASP3 PIK3R1 PIK3R1 ENSPPYP00000018466 ENSPPYP00000018466 CDKN1A CDKN1A GSTA1 GSTA1 GSTA5 GSTA5 GSTA3 GSTA3 GSTA4 GSTA4 REV3L REV3L MAP3K5 MAP3K5 POLH POLH CYCS CYCS ENSPPYP00000021735 ENSPPYP00000021735 XPA XPA SLC31A1 SLC31A1 ATP7A ATP7A XIAP XIAP PIK3CA PIK3CA MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
MGST3MGST3 isoform 3. (152 aa)
GSTM3Glutathione S-transferase. (225 aa)
GSTM5GSTM1 isoform 5; Belongs to the GST superfamily. (218 aa)
GSTM1Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (218 aa)
GSTM2Glutathione S-transferase Mu 2. (87 aa)
GSTM4GSTM4 isoform 6; Belongs to the GST superfamily. (218 aa)
PIK3R3T0148502 isoform 1. (461 aa)
CASP9CASP9 isoform 2; Belongs to the peptidase C14A family. (421 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
ABCC2ATP binding cassette subfamily C member 2. (1545 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
GSTP1Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (323 aa)
BADBCL2 associated agonist of cell death. (168 aa)
BIRC2Baculoviral IAP repeat containing 2. (597 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ATP7BATP7B isoform 3. (1434 aa)
BAK1Bcl-2 homologous antagonist/killer. (147 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1553 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
BCL2BCL2 isoform 1. (238 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
BBC3BBC3 isoform 5. (193 aa)
BCL2L1BCL2L1 isoform 2. (233 aa)
CR201_G0053650Uncharacterized protein. (240 aa)
ENSPPYP00000013389Glutathione S-transferase theta-4. (107 aa)
BID-2BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (227 aa)
LOC100461022GSTT2B isoform 1; Belongs to the GST superfamily. (244 aa)
CR201_G0053647GSTTP1 isoform 1. (68 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
MLH1MLH1 isoform 1. (725 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1621 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
CASP3CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
ENSPPYP00000018466Cytochrome c-like. (105 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
GSTA1GSTA2 isoform 1. (222 aa)
GSTA5LOW QUALITY PROTEIN: glutathione S-transferase A5. (221 aa)
GSTA3GSTA3 isoform 1. (222 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
REV3LREV3L isoform 3. (3117 aa)
MAP3K5MAP3K5 isoform 1. (1327 aa)
POLHPOLH isoform 1. (516 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
ENSPPYP00000021735Cytochrome c-like. (38 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
SLC31A1High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. (190 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
XIAPXIAP isoform 2. (513 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.