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RXRG RXRG HMGCS2 HMGCS2 CPT2 CPT2 SCP2 SCP2 CYP4A11 CYP4A11 FABP3 FABP3 SCD SCD ACSL5 ACSL5 CPT1A CPT1A FADS2 FADS2 NR1H3 NR1H3 ME3 ME3 MMP1 MMP1 APOC3 APOC3 APOA1 APOA1 UBC UBC PCK2 PCK2 ACSBG1 ACSBG1 PLIN1 PLIN1 PLIN4 PLIN4 PLIN5 PLIN5 ANGPTL4 ANGPTL4 SLC27A1 SLC27A1 SLC27A5 SLC27A5 CPT1C CPT1C PCK1 PCK1 CPT1B CPT1B FABP1 FABP1 DBI DBI CR201_G0032337-2 CR201_G0032337-2 PPARG PPARG ACOX2 ACOX2 CYP8B1 CYP8B1 ACAA1 ACAA1 EHHADH EHHADH ADIPOQ ADIPOQ ACOX3 ACOX3 GK2 GK2 SCD5 SCD5 FABP2 FABP2 UCP1 UCP1 GK3P GK3P ACSL1 ACSL1 HMGCS1 HMGCS1 SLC27A6 SLC27A6 FABP6 FABP6 PPARD PPARD ME1 ME1 FABP7 FABP7 RXRB RXRB CD36 CD36 LPL LPL CYP7A1 CYP7A1 FABP5 FABP5 FABP9 FABP9 FABP4 FABP4 AQP7 AQP7 PLIN2 PLIN2 GK GK ACSL4 ACSL4 ILK ILK ACSL3 ACSL3 SLC27A2 SLC27A2 OLR1 OLR1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (462 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
SCP2SCP2 isoform 1; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
CYP4A11CYP4A22 isoform 5; Belongs to the cytochrome P450 family. (519 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
ACSL5ACSL5 isoform 4. (705 aa)
CPT1ACPT1A isoform 3; Belongs to the carnitine/choline acetyltransferase family. (526 aa)
FADS2Acyl-CoA 6-desaturase; Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic [...] (444 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
ME3Malic enzyme. (604 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
APOC3Apolipoprotein C3. (99 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (219 aa)
UBCUBC isoform 2. (625 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (724 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
PLIN4PLIN4 isoform 1. (940 aa)
PLIN5Perilipin-5. (460 aa)
ANGPTL4Angiopoietin like 4. (406 aa)
SLC27A1SLC27A1 isoform 2. (645 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
CPT1CCPT1C isoform 2; Belongs to the carnitine/choline acetyltransferase family. (572 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. (622 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
FABP1Fatty acid binding protein 1. (127 aa)
DBIDBI isoform 2. (104 aa)
CR201_G0032337-2CYP27A1 isoform 5. (382 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
EHHADHEnoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (707 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ACOX3Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids. (676 aa)
GK2GK2 isoform 1; Belongs to the FGGY kinase family. (553 aa)
SCD5SCD5 isoform 1; Belongs to the fatty acid desaturase type 1 family. (256 aa)
FABP2Fatty acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
GK3PGK3P isoform 1; Belongs to the FGGY kinase family. (553 aa)
ACSL1ACSL1 isoform 4. (748 aa)
HMGCS1Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
SLC27A6SLC27A6 isoform 1. (621 aa)
FABP6FABP6 isoform 3. (128 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ME1Malic enzyme. (538 aa)
FABP7FABP7 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
RXRBRetinoid X receptor beta. (536 aa)
CD36CD36 isoform 15; Belongs to the CD36 family. (472 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (80 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
FABP5FABP5 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
FABP9FABP9 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
AQP7AQP7 isoform 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (198 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
GKGK isoform 3; Belongs to the FGGY kinase family. (530 aa)
ACSL4ACSL4 isoform 2. (670 aa)
ILKIntegrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa)
ACSL3Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] (720 aa)
SLC27A2SLC27A2 isoform 1. (637 aa)
OLR1Oxidized low density lipoprotein receptor 1. (273 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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