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| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | RGS2 | RGS2 isoform 1. (210 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa) |
| | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha. (1000 aa) |
| | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1020 aa) |
| | MEF2D | MEF2D isoform 1. (520 aa) |
| | NPR1 | Guanylate cyclase. (1054 aa) |
| | TMIGD3 | TMIGD3 isoform 3; Belongs to the G-protein coupled receptor 1 family. (346 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (376 aa) |
| | NPPB | Natriuretic peptide B. (134 aa) |
| | NPPA | Natriuretic peptide A. (159 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | CALML5 | Calmodulin like 5. (146 aa) |
| | CALML3 | CALML3 isoform 1; Belongs to the calmodulin family. (149 aa) |
| | PPIF | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (209 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (438 aa) |
| | PRKG1 | PRKG1 isoform 4; Belongs to the protein kinase superfamily. (251 aa) |
| | ADRA2A | ADRA2A isoform 1. (450 aa) |
| | ADRB1 | ADRB1 isoform 1. (345 aa) |
| | INS-IGF2 | INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa) |
| | PDE3B | Phosphodiesterase. (1115 aa) |
| | PDE2A | Phosphodiesterase. (939 aa) |
| | GUCY1A2 | GUCY1A2 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (734 aa) |
| | LOC103891919 | Sodium/potassium-transporting ATPase subunit gamma isoform X1. (66 aa) |
| | KCNJ8 | Potassium voltage-gated channel subfamily J member 8. (424 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | ADCY6 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa) |
| | KCNMB4 | Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa) |
| | ATP2B1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1173 aa) |
| | ATP2A2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (950 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa) |
| | MYH7 | MYH7 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1896 aa) |
| | ADCY4 | Adenylate cyclase type 4 isoform X1. (1077 aa) |
| | NFATC4 | NFATC4 isoform 21. (868 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | MAP2K1 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa) |
| | CALML4 | LOW QUALITY PROTEIN: calmodulin-like protein 4. (196 aa) |
| | MEF2A | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (494 aa) |
| | ADCY9 | ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (994 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | ADCY7 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa) |
| | CNGB1 | CNGB1 isoform 1. (1175 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1068 aa) |
| | MYLK3 | Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (819 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (905 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa) |
| | PIK3R6 | PIK3R6 isoform 2. (696 aa) |
| | PIK3R5 | PIK3R5 isoform 10. (883 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa) |
| | GNA11 | GNA11 isoform 1. (358 aa) |
| | MEF2B | MEF2B isoform 4. (382 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | VASP | Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa) |
| | MAP2K2 | MAP2K2 isoform 6. (213 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa) |
| | ADRA1D | Adrenoceptor alpha 1D. (573 aa) |
| | MYL9 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | ATF4 | ATF4 isoform 1. (352 aa) |
| | ADRA2B | Adrenoceptor alpha 2B. (452 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (327 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | CREB1 | CREB1 isoform 1. (341 aa) |
| | NPPC | Natriuretic peptide C. (126 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] (648 aa) |
| | MYLK | MYLK isoform 5. (1913 aa) |
| | ATP2B2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa) |
| | ITPR1 | ITPR1 isoform 3. (2769 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2077 aa) |
| | GNAI2 | GNAI2 isoform 1. (303 aa) |
| | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa) |
| | AGTR1 | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | KCNMB2 | T0034024 isoform 1. (235 aa) |
| | KCNMB3 | KCNMB3 isoform 7. (256 aa) |
| | KNG1 | KNG1 isoform 1. (427 aa) |
| | CNGA1 | CNGA1 isoform 1. (690 aa) |
| | PRKG2 | cGMP-dependent protein kinase. (762 aa) |
| | PDE5A | Phosphodiesterase. (833 aa) |
| | SLC25A31 | SLC25A31 isoform 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (253 aa) |
| | EDNRA | EDNRA isoform 1; Belongs to the G-protein coupled receptor 1 family. (425 aa) |
| | GUCY1B1 | GUCY1B3 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | GUCY1A1 | GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (264 aa) |
| | ADRB2 | Adrenoceptor beta 2. (415 aa) |
| | ADRA1B | ADRA1B isoform 3. (517 aa) |
| | KCNMB1 | KCNMB1 isoform 1. (191 aa) |
| | MYLK4 | MYLK4 isoform 1; Belongs to the protein kinase superfamily. (388 aa) |
| | ATF6B | ATF6B isoform 2. (721 aa) |
| | ITPR3 | ITPR3 isoform 1. (2641 aa) |
| | SRF | Serum response factor. (508 aa) |
| | GNA12 | GNA12 isoform 1. (381 aa) |
| | GTF2I | GTF2I isoform 2. (974 aa) |
| | GTF2IRD1 | GTF2IRD1 isoform 4. (959 aa) |
| | ADCY1 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa) |
| | PIK3CG | PIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | CREB3L2 | Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (520 aa) |
| | NOS3 | NOS3 isoform 2. (833 aa) |
| | GATA4 | GATA binding protein 4. (442 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (511 aa) |
| | ADRA1A | Adrenoceptor alpha 1A. (427 aa) |
| | ADRB3 | ADRB3 isoform 1. (408 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (283 aa) |
| | PLN | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa) |
| | LOC100455662 | Calmodulin-alpha-like. (149 aa) |
| | ADCY8 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa) |
| | NPR2 | Guanylate cyclase. (1046 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | ENSPPYP00000021457 | Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. (72 aa) |
| | GNAQ | G protein subunit alpha q. (359 aa) |
| | IRS4 | Insulin receptor substrate 4. (1262 aa) |
| | SLC25A5 | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). (530 aa) |
| | ATP1B4 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (250 aa) |
| | ATP2B3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1120 aa) |
| | MAPK1 | Mitogen-activated protein kinase 1 isoform X1. (158 aa) |
| | MRVI1 | MRVI1 isoform 6. (904 aa) |
| | EDNRB | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
