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| | CDC14A | Cell division cycle 14A. (594 aa) |
| | CDC7 | Cell division cycle 7. (574 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa) |
| | SFN | SFN isoform 1; Belongs to the 14-3-3 family. (248 aa) |
| | E2F2 | E2F2 isoform 1. (437 aa) |
| | ZBTB17 | Zinc finger and BTB domain containing 17. (807 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] (297 aa) |
| | SMC3 | Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity); Belongs to the SMC family. SMC3 [...] (1217 aa) |
| | BUB3 | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] (328 aa) |
| | CDKN1C | CDKN1C isoform 4. (131 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (173 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa) |
| | CCND2 | CCND2 isoform 1; Belongs to the cyclin family. (289 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | ESPL1 | ESPL1 isoform 1. (2075 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | CDK4 | CDK4 isoform 2; Belongs to the protein kinase superfamily. (317 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (755 aa) |
| | CCNA1 | CCNA1 isoform 3; Belongs to the cyclin family. (464 aa) |
| | RB1 | RB1 isoform 1. (928 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1050 aa) |
| | CCNB2 | CCNB2 isoform 1; Belongs to the cyclin family. (398 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | PKMYT1 | PKMYT1 isoform 10; Belongs to the protein kinase superfamily. (499 aa) |
| | CREBBP | CREBBP isoform 1. (2328 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | RBL2 | RBL2 isoform 2. (1140 aa) |
| | E2F4 | E2F transcription factor 4. (411 aa) |
| | ORC6 | ORC6 isoform 2. (295 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | CDC27 | CDC27 isoform 1. (824 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | GADD45B | GADD45B isoform 5. (148 aa) |
| | CDKN2D | CDKN2D isoform 1. (166 aa) |
| | CCNE1 | CCNE1 isoform 1; Belongs to the cyclin family. (410 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | E2F1 | E2F1 isoform 1. (361 aa) |
| | RBL1 | RBL1 isoform 1. (1068 aa) |
| | YWHAB | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] (262 aa) |
| | CHEK2 | CHEK2 isoform 5. (520 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | EP300 | EP300 isoform 1. (2380 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1233 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1082 aa) |
| | ANAPC1 | ANAPC1 isoform 2. (1855 aa) |
| | YWHAQ | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). (245 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (822 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). (436 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | ANAPC13 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC13 family. (74 aa) |
| | TFDP2 | Transcription factor. (446 aa) |
| | ATR | ATR isoform 1; Belongs to the PI3/PI4-kinase family. (2636 aa) |
| | ZCCHC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (1106 aa) |
| | MAD2L1 | MAD2L1 isoform 1. (300 aa) |
| | CCNA2 | CCNA2 isoform 1; Belongs to the cyclin family. (432 aa) |
| | SKP2 | SKP2 isoform 1. (410 aa) |
| | CCNB1 | CCNB1 isoform 1; Belongs to the cyclin family. (433 aa) |
| | CDK7 | CDK7 isoform 1; Belongs to the protein kinase superfamily. (346 aa) |
| | CCNH | CCNH isoform 4; Belongs to the cyclin family. (323 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | PTTG1 | PTTG1 regulator of sister chromatid separation, securin. (202 aa) |
| | E2F3 | E2F3 isoform 2. (427 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | CCND3 | CCND3 isoform 1; Belongs to the cyclin family. (292 aa) |
| | MCM3 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (764 aa) |
| | TTK | TTK isoform 4. (855 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | HDAC2 | Histone deacetylase 2. (580 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | YWHAG | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. (247 aa) |
| | ENSPPYP00000019690 | LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14C. (459 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | DBF4 | DBF4 isoform 1. (673 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | WEE2 | Wee1-like protein kinase. (567 aa) |
| | PRKDC | PRKDC isoform 1; Belongs to the PI3/PI4-kinase family. (3972 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | YWHAZ | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity); Belongs to the 14-3-3 family. (245 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | MYC | MYC isoform 1. (453 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (137 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | CDC14B | Cell division cycle 14B. (498 aa) |
| | CDC26 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | ABL1 | Tyrosine-protein kinase. (948 aa) |
| | LOC100457325 | Transcription factor Dp-1. (408 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1196 aa) |
| | STAG2 | STAG2 isoform 10. (1242 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | ENSPPYP00000024179 | 14-3-3 protein epsilon-like isoform X1. (173 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
