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| | COP1 | COP1 E3 ubiquitin ligase. (731 aa) |
| | UBE2Q1 | Ubiquitin conjugating enzyme E2 Q1. (422 aa) |
| | PIAS3 | PIAS3 isoform 3. (619 aa) |
| | UBE2U | UBE2U isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (226 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | FBXO2 | F-box protein 2. (295 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (259 aa) |
| | HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | SYVN1 | SYVN1 isoform 3. (616 aa) |
| | PRPF19 | PRPF19 isoform 1. (523 aa) |
| | UBE2L6 | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (597 aa) |
| | UBE4A | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. (1072 aa) |
| | CBL | Cbl proto-oncogene. (905 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | UBE3B | UBE3B isoform 1. (1068 aa) |
| | FBXW8 | FBXW8 isoform 2. (596 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (755 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | CUL4A | CUL4A isoform 5; Belongs to the cullin family. (759 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (849 aa) |
| | HERC2 | LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2. (1493 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (937 aa) |
| | PIAS1 | PIAS1 isoform 1. (683 aa) |
| | DET1 | DET1 isoform 5. (472 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ELOB | ELOB isoform 1. (160 aa) |
| | MGRN1 | MGRN1 isoform 2. (576 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (213 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (874 aa) |
| | UBE2G1 | Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | UBB | UBB isoform 2. (229 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (877 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1293 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (225 aa) |
| | TRIM37 | TRIM37 isoform 1. (946 aa) |
| | CDC27 | CDC27 isoform 1. (824 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (621 aa) |
| | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] (964 aa) |
| | CDC34 | CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa) |
| | PIAS4 | PIAS4 isoform 1. (381 aa) |
| | KEAP1 | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa) |
| | UBA52 | UBA52 isoform 10. (128 aa) |
| | UBA2 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (544 aa) |
| | SAE1 | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. (382 aa) |
| | UBE2S | UBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | UBE2M | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | UBOX5 | UBOX5 isoform 2. (512 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (280 aa) |
| | UBE2G2 | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). (165 aa) |
| | UBE2L3 | Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa) |
| | PPIL2 | PPIL2 isoform 1. (495 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | ANAPC1 | ANAPC1 isoform 2. (1855 aa) |
| | FANCL | FA complementation group L. (375 aa) |
| | BIRC6 | BIRC6 isoform 1. (4803 aa) |
| | UBE2E3 | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa) |
| | CUL3 | CUL3 isoform 1; Belongs to the cullin family. (768 aa) |
| | TRIP12 | TRIP12 isoform 4. (2039 aa) |
| | UBE2F | UBE2F isoform 2; Belongs to the ubiquitin-conjugating enzyme family. (185 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | VHL | VHL isoform 1. (213 aa) |
| | UBA3 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity). (484 aa) |
| | UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) |
| | UBE2E2 | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | ANAPC13 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC13 family. (74 aa) |
| | RNF7 | Ring finger protein 7. (113 aa) |
| | ZCCHC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (1106 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | UBA6 | UBA6 isoform 1. (1052 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | HERC3 | HERC3 isoform 11. (1050 aa) |
| | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa) |
| | FBXW7 | FBXW7 isoform 8. (627 aa) |
| | UBE2QL1 | UBE2QL1 isoform 1. (161 aa) |
| | SKP2 | SKP2 isoform 1. (410 aa) |
| | FBXO4 | FBXO4 isoform 2. (387 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1505 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa) |
| | CUL7 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] (1723 aa) |
| | UBE2J1 | Ubiquitin conjugating enzyme E2 J1. (318 aa) |
| | UBE2H | Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | UBE3C | UBE3C isoform 2. (1080 aa) |
| | RHOBTB2 | RHOBTB2 isoform 4. (734 aa) |
| | ELOC | ELOC isoform 10; Belongs to the SKP1 family. (112 aa) |
| | UBR5 | UBR5 isoform 1. (2695 aa) |
| | UBE2R2 | Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | KLHL9 | Kelch like family member 9. (617 aa) |
| | CDC26 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | CUL2 | Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...] (745 aa) |
| | UBA1 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. (1056 aa) |
| | HUWE1 | HUWE1 isoform 1. (4373 aa) |
| | KLHL13 | KLHL13 isoform 9. (586 aa) |
| | UBE2A | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | XIAP | XIAP isoform 2. (513 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) |
| | UBE2D4 | UBE2D4 isoform 3; Belongs to the ubiquitin-conjugating enzyme family. (171 aa) |
| | RHOBTB1 | RHOBTB1 isoform 1. (696 aa) |
| | HERC1 | HERC1 isoform 5. (2747 aa) |
