STRINGSTRING
STX6 STX6 SEC22B SEC22B VAMP3 VAMP3 VTI1A VTI1A STX5 STX5 STX3 STX3 VAMP1 VAMP1 STX2 STX2 VTI1B VTI1B SNAP23 SNAP23 STX1B STX1B STX4 STX4 VAMP2 VAMP2 STX8 STX8 GOSR1 GOSR1 GOSR2 GOSR2 USE1 USE1 SNAP29 SNAP29 VAMP8 VAMP8 STX19 STX19 STX7 STX7 STX11 STX11 STX1A STX1A YKT6 YKT6 STX17 STX17 BET1L BET1L VAMP7 VAMP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STX6Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
STX3STX3 isoform 3; Belongs to the syntaxin family. (289 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
STX2STX2 isoform 2; Belongs to the syntaxin family. (263 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
STX1BSTX1B isoform 1; Belongs to the syntaxin family. (590 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
VAMP2VAMP2 isoform 2. (116 aa)
STX8STX8 isoform 2. (236 aa)
GOSR1Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] (248 aa)
GOSR2T0082108 isoform 1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
USE1Unconventional SNARE in the endoplasmic reticulum protein 1. (259 aa)
SNAP29Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. (258 aa)
VAMP8Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa)
STX19Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR). (294 aa)
STX7Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa)
STX11STX11 isoform 1; Belongs to the syntaxin family. (287 aa)
STX1ASyntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] (259 aa)
YKT6YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa)
STX17STX17 isoform 1; Belongs to the syntaxin family. (302 aa)
BET1LBET1-like protein; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). (111 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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