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LOC100452886 LOC100452886 ATP6V1G3 ATP6V1G3 NCF2 NCF2 FCGR2B FCGR2B CR201_G0042089 CR201_G0042089 FCGR2A FCGR2A CTSS CTSS SEC22B SEC22B ATP6V0B ATP6V0B VAMP3 VAMP3 TUBAL3 TUBAL3 SEC61A2 SEC61A2 MRC1 MRC1 ITGB1 ITGB1 SFTPD SFTPD ENSPPYP00000002671 ENSPPYP00000002671 CR201_G0030124 CR201_G0030124 MBL2 MBL2 ENSPPYP00000003272 ENSPPYP00000003272 CR201_G0030121 CR201_G0030121 TCIRG1 TCIRG1 M6PR M6PR CLEC7A CLEC7A ITGA5 ITGA5 RAB5B RAB5B NOS1 NOS1 ATP6V0A2 ATP6V0A2 SCARB1 SCARB1 ATP6V1D ATP6V1D CR201_G0055131 CR201_G0055131 ENSPPYP00000007081 ENSPPYP00000007081 THBS1 THBS1 ATP6V0C ATP6V0C ATP6V0D1 ATP6V0D1 TUBB3 TUBB3 RILP RILP MPO MPO ATP6V0A1 ATP6V0A1 RAB5C RAB5C ACTG1 ACTG1 ITGB3 ITGB3 TUBB6 TUBB6 COLEC12 COLEC12 PIK3C3 PIK3C3 C3 C3 CLEC4M CLEC4M CALR CALR TUBB1 TUBB1 ITGB2 ITGB2 NCF4 NCF4 ATP6V1B1 ATP6V1B1 ATP6V1E2 ATP6V1E2 ATP6V1C2 ATP6V1C2 COLEC11 COLEC11 PLA2R1 PLA2R1 DYNC1I2 DYNC1I2 PIKFYVE PIKFYVE TUBA4A TUBA4A RAB7A RAB7A SEC61A1 SEC61A1 ITGB5 ITGB5 ATP6V1A ATP6V1A DYNC1LI1 DYNC1LI1 RAB5A RAB5A TFRC TFRC TLR6 TLR6 TLR2 TLR2 CD14 CD14 TUBB2B TUBB2B Poab-F Poab-F HLA-A HLA-A HLA-E HLA-E TUBB TUBB ATP6V1G2 ATP6V1G2 HLA-DRB5 HLA-DRB5 ENSPPYP00000018441 ENSPPYP00000018441 CR201_G0016196 CR201_G0016196 HLA-DOA HLA-DOA STX7 STX7 CR201_G0055889 CR201_G0055889 ENSPPYP00000019293 ENSPPYP00000019293 ENSPPYP00000019298 ENSPPYP00000019298 HLA-DQB2 HLA-DQB2 HLA-DOB HLA-DOB TAP2 TAP2 TAP1 TAP1 LOC100448477 LOC100448477 HLA-DMA HLA-DMA CR201_G0016219 CR201_G0016219 LOC100460187 LOC100460187 CR201_G0016218-2 CR201_G0016218-2 CR201_G0055693 CR201_G0055693 CR201_G0042422-3 CR201_G0042422-3 ENSPPYP00000019353 ENSPPYP00000019353 THBS2 THBS2 ACTB ACTB NCF1 NCF1 SEC61G SEC61G DYNC1I1 DYNC1I1 CD36 CD36 ATP6V1F ATP6V1F ATP6V0A4 ATP6V0A4 MSR1 MSR1 ATP6V1B2 ATP6V1B2 ATP6V1H ATP6V1H ATP6V0D2 ATP6V0D2 ATP6V1C1 ATP6V1C1 CTSL CTSL SEC61B SEC61B TLR4 TLR4 LOC100434822 LOC100434822 LOC100431914 LOC100431914 CYBB CYBB LAMP2 LAMP2 ATP6AP1 ATP6AP1 CR201_G0054189-2 CR201_G0054189-2 ATP6V1G1 ATP6V1G1 CR201_G0042434 CR201_G0042434 ATP6V0E1 ATP6V0E1 TUBA8 TUBA8 TUBA1C TUBA1C OLR1 OLR1 TUBA1B TUBA1B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC100452886TUBB8 isoform 7. (440 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
NCF2NCF2 isoform 3. (526 aa)
FCGR2BFCGR2B isoform 1. (303 aa)
CR201_G0042089FCGR3A isoform 7. (290 aa)
FCGR2AFc fragment of IgG receptor IIa. (314 aa)
CTSSCTSS isoform 1; Belongs to the peptidase C1 family. (330 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
ATP6V0BATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family. (156 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
SEC61A2Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). (476 aa)
MRC1MRC1 isoform 1. (1455 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (887 aa)
SFTPDSurfactant protein D. (375 aa)
ENSPPYP00000002671LOW QUALITY PROTEIN: mannose-binding protein A-like. (187 aa)
CR201_G0030124SFTPA2 isoform 3. (248 aa)
MBL2MBL2 isoform 1. (248 aa)
ENSPPYP00000003272LOW QUALITY PROTEIN: cathepsin L1-like. (215 aa)
CR201_G0030121SFTPA1 isoform 2. (248 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (559 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
CLEC7ACLEC7A isoform 1. (247 aa)
ITGA5ITGA5 isoform 1; Belongs to the integrin alpha chain family. (1078 aa)
RAB5BRas-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity). (285 aa)
NOS1NOS1 isoform 2. (1456 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
SCARB1SCARB1 isoform 7; Belongs to the CD36 family. (471 aa)
ATP6V1DV-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). (247 aa)
CR201_G0055131IGHV3-21 isoform 1. (132 aa)
ENSPPYP00000007081Immunoglobulin delta heavy chain-like. (117 aa)
THBS1Thrombospondin 1. (1170 aa)
ATP6V0CV-type H+-transporting ATPase 16kDa proteolipid subunit. (128 aa)
ATP6V0D1V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] (351 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
RILPRILP isoform 2. (400 aa)
MPOMyeloperoxidase. (745 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (862 aa)
RAB5CRas-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (216 aa)
ACTG1ACTG1 isoform 10. (375 aa)
ITGB3Integrin beta. (788 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
COLEC12COLEC12 isoform 1. (800 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
C3C3 isoform 1. (1664 aa)
CLEC4MCD209 isoform 4. (306 aa)
CALRCalreticulin. (417 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
ITGB2Integrin beta. (768 aa)
NCF4NCF4 isoform 3. (339 aa)
ATP6V1B1V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (509 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (389 aa)
COLEC11Collectin subfamily member 11. (271 aa)
PLA2R1Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marro [...] (1463 aa)
DYNC1I2Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and help dynein bind to dynactin 150 kDa component (By similarity). organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such a [...] (638 aa)
PIKFYVEPIKFYVE isoform 1. (2088 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa)
SEC61A1Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] (476 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (732 aa)
ATP6V1AV-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (578 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (760 aa)
TLR6Toll-like receptor. (796 aa)
TLR2Toll-like receptor. (783 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (343 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
Poab-FMHC class I protein; Belongs to the MHC class I family. (346 aa)
HLA-APopy Class I histocompatibility antigen, A-1 alpha chain. (365 aa)
HLA-EHLA-E isoform 1; Belongs to the MHC class I family. (387 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (444 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
HLA-DRB5Ig-like domain-containing protein. (266 aa)
ENSPPYP00000018441HLA class II histocompatibility antigen, DQ alpha 2 chain. (190 aa)
CR201_G0016196HLA-DQB1 isoform 5. (304 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
STX7Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa)
CR201_G0055889Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
ENSPPYP00000019293HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa)
ENSPPYP00000019298HLA class II histocompatibility antigen, DQ alpha 2 chain. (63 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain. (272 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (703 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
LOC100448477HLA-DMB isoform 5. (263 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X1. (261 aa)
CR201_G0016219HLA-DPB1 isoform 1. (283 aa)
LOC100460187MHC class II protein; Belongs to the MHC class II family. (254 aa)
CR201_G0016218-2HLA-DPA1 isoform 3. (239 aa)
CR201_G0055693HLA-B isoform 1; Belongs to the MHC class I family. (362 aa)
CR201_G0042422-3HLA-G isoform 6. (259 aa)
ENSPPYP00000019353HLA class I histocompatibility antigen, alpha chain G isoform X1. (66 aa)
THBS2THBS2 isoform 1. (655 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
NCF1NCF1 isoform 3. (364 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
CD36CD36 isoform 15; Belongs to the CD36 family. (472 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (876 aa)
MSR1MSR1 isoform 2. (416 aa)
ATP6V1B2V-type proton ATPase subunit B, brain isoform. (278 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (465 aa)
ATP6V0D2V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V1C1V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (382 aa)
CTSLCTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
SEC61BProtein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity). (96 aa)
TLR4TLR4 isoform 1; Belongs to the Toll-like receptor family. (804 aa)
LOC100434822TUBA3C isoform 1. (450 aa)
LOC100431914FCGR1A isoform 2. (373 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
LAMP2Lysosomal associated membrane protein 2. (410 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (475 aa)
CR201_G0054189-2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ATP6V1G1V-type H+-transporting ATPase subunit G. (115 aa)
CR201_G0042434HLA-A isoform 3; Belongs to the MHC class I family. (362 aa)
ATP6V0E1V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (476 aa)
OLR1Oxidized low density lipoprotein receptor 1. (273 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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