STRINGSTRING
GREM2 GREM2 LEFTY2 LEFTY2 ENSPPYP00000000171 ENSPPYP00000000171 FMOD FMOD HJV HJV ZFYVE9 ZFYVE9 BMP8B BMP8B ID3 ID3 NBL1 NBL1 BAMBI BAMBI BMPR1A BMPR1A NODAL NODAL RPS6KB2 RPS6KB2 ACVR1B ACVR1B SP1 SP1 AMHR2 AMHR2 INHBE INHBE IFNG IFNG DCN DCN BMP4 BMP4 TGFB3 TGFB3 GREM1 GREM1 THBS1 THBS1 FBN1 FBN1 SMAD6 SMAD6 SMAD3 SMAD3 THSD4 THSD4 NEO1 NEO1 CREBBP CREBBP MAPK3 MAPK3 E2F4 E2F4 NOG NOG SMURF2 SMURF2 RPS6KB1 RPS6KB1 TGIF1 TGIF1 ROCK1 ROCK1 SMAD2 SMAD2 SMAD7 SMAD7 SMAD4 SMAD4 AMH AMH HAMP HAMP TGFB1 TGFB1 PPP2R1A PPP2R1A ID1 ID1 GDF5 GDF5 RBL1 RBL1 RBX1 RBX1 EP300 EP300 GDF7 GDF7 ID2 ID2 INHBB INHBB ACVR2A ACVR2A ACVR1 ACVR1 BMPR2 BMPR2 ACVR2B ACVR2B TGFBR2 TGFBR2 CHRD CHRD BMPR1B BMPR1B PITX2 PITX2 SMAD1 SMAD1 SMAD9 SMAD9 FST FST ZFYVE16 ZFYVE16 RGMB RGMB SKP1 SKP1 SMAD5 SMAD5 BMP6 BMP6 TNF TNF BMP5 BMP5 INHBA INHBA PPP2CB PPP2CB GDF6 GDF6 MYC MYC CDKN2B CDKN2B TGFBR1 TGFBR1 LOC100457325 LOC100457325 TFDP1 TFDP1 MAPK1 MAPK1 ID4 ID4 BMP2 BMP2 TGIF2 TGIF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GREM2Gremlin. (168 aa)
LEFTY2Left-right determination factor. (366 aa)
ENSPPYP00000000171Left-right determination factor 1 isoform X1. (366 aa)
FMODFMOD isoform 1. (376 aa)
HJVHFE2 isoform 3. (425 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1390 aa)
BMP8BBMP8B isoform 1. (336 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (181 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNodal growth differentiation factor. (347 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
SP1Sp1 transcription factor. (786 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
INHBEInhibin subunit beta E. (350 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GREM1Gremlin. (184 aa)
THBS1Thrombospondin 1. (1170 aa)
FBN1FBN1 isoform 1. (2871 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
THSD4THSD4 isoform 1. (1017 aa)
NEO1NEO1 isoform 1. (1444 aa)
CREBBPCREBBP isoform 1. (2328 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
E2F4E2F transcription factor 4. (411 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMURF2E3 ubiquitin-protein ligase. (877 aa)
RPS6KB1T0040019 isoform 1. (525 aa)
TGIF1TGIF1 isoform 12. (272 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AMHAMH isoform 1. (561 aa)
HAMPHepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. (85 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
PPP2R1APPP2R1A isoform 7. (558 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
GDF5Growth differentiation factor 5. (501 aa)
RBL1RBL1 isoform 1. (1068 aa)
RBX1RBX1 isoform 1. (108 aa)
EP300EP300 isoform 1. (2380 aa)
GDF7GDF7 isoform 1. (447 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
INHBBINHBB isoform 1. (273 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (938 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (492 aa)
PITX2Homeobox protein. (317 aa)
SMAD1Mothers against decapentaplegic homolog. (73 aa)
SMAD9LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 9. (47 aa)
FSTFST isoform 1. (344 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1539 aa)
RGMBRGMB isoform 2. (591 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
SMAD5Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
BMP6BMP6 isoform 1. (510 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
BMP5BMP5 isoform 1. (453 aa)
INHBAInhibin subunit beta A. (426 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
GDF6Growth differentiation factor 6. (455 aa)
MYCMYC isoform 1. (453 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (137 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
LOC100457325Transcription factor Dp-1. (408 aa)
TFDP1Transcription factor. (410 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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