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| | ENAH | ENAH isoform 1. (579 aa) |
| | PLXNA2 | PLXNA2 isoform 1. (1923 aa) |
| | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2. (1071 aa) |
| | EFNA1 | EFNA1 isoform 1; Belongs to the ephrin family. (205 aa) |
| | EFNA3 | Ephrin-A3 isoform X1. (238 aa) |
| | EFNA4 | EFNA4 isoform 1; Belongs to the ephrin family. (201 aa) |
| | SEMA6C | SEMA6C isoform 1; Belongs to the semaphorin family. (932 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa) |
| | PIK3R3 | T0148502 isoform 1. (461 aa) |
| | EPHA8 | EPHA8 isoform 1. (734 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | CDC42 | Cell division cycle 42. (191 aa) |
| | EPHA2 | EPHA2 isoform 1. (959 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (887 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | PARD3 | PARD3 isoform 5. (1353 aa) |
| | CXCL12 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (438 aa) |
| | UNC5B | UNC5B isoform 2. (658 aa) |
| | SEMA4G | SEMA4G isoform 7; Belongs to the semaphorin family. (811 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | SSH3 | SSH3 isoform 1. (637 aa) |
| | RHOD | Ras homolog family member D. (210 aa) |
| | CFL1 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. (165 aa) |
| | LRRC4C | Leucine rich repeat containing 4C. (640 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (546 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | ROBO3 | ROBO3 isoform 3. (1493 aa) |
| | WNT5B | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (359 aa) |
| | RND1 | Rho family GTPase 1. (232 aa) |
| | SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1. (1085 aa) |
| | NTN4 | Netrin-4; May play an important role in neural, kidney and vascular development. (628 aa) |
| | SSH1 | SSH1 isoform 1. (1004 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa) |
| | EFNB2 | EFNB2 isoform 1; Belongs to the ephrin family. (333 aa) |
| | NFATC4 | NFATC4 isoform 21. (868 aa) |
| | CFL2 | CFL2 isoform 1; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | PAK6 | Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase fam [...] (681 aa) |
| | NEO1 | NEO1 isoform 1. (1444 aa) |
| | SEMA7A | SEMA7A isoform 1; Belongs to the semaphorin family. (664 aa) |
| | SEMA4B | SEMA4B isoform 4. (930 aa) |
| | FES | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | NTN3 | NTN3 isoform 1. (483 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | PARD6A | Par-6 family cell polarity regulator alpha. (346 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1068 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa) |
| | RAC3 | RAC3 isoform 1. (192 aa) |
| | MYL12B | Myosin light chain 12B. (172 aa) |
| | MYL12A | Myosin regulatory light chain 12A; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (177 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa) |
| | DCC | DCC isoform 2. (1419 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (645 aa) |
| | RRAS | RRAS isoform 1. (218 aa) |
| | MYL9 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa) |
| | PARD6B | Par-6 family cell polarity regulator beta. (372 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | PAK7 | Non-specific serine/threonine protein kinase. (266 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | PLXNB2 | PLXNB2 isoform 4. (1872 aa) |
| | NCK2 | Cytoplasmic protein. (380 aa) |
| | DPYSL5 | DPYSL5 isoform 2. (529 aa) |
| | GDF7 | GDF7 isoform 1. (447 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | CXCR4 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | EPHA4 | EPHA4 isoform 2. (927 aa) |
| | NGEF | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). (708 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] (648 aa) |
| | PLXNA1 | PLXNA1 isoform 1. (1944 aa) |
| | SEMA5B | SEMA5B isoform 1. (1091 aa) |
| | BOC | BOC isoform 3. (1110 aa) |
| | EPHA6 | EPHA6 isoform 2. (766 aa) |
| | ROBO1 | ROBO1 isoform 6. (1612 aa) |
| | EPHA3 | EPHA3 isoform 1. (983 aa) |
| | SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3. (1075 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa) |
| | SEMA3G | SEMA3G isoform 1; Belongs to the semaphorin family. (878 aa) |
| | GNAI2 | GNAI2 isoform 1. (303 aa) |
| | SEMA3F | SEMA3F isoform 4; Belongs to the semaphorin family. (755 aa) |
| | RYK | RYK isoform 3. (535 aa) |
| | EPHB1 | EPHB1 isoform 1. (1057 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (502 aa) |
| | MYL5 | MYL5 isoform 1. (172 aa) |
| | EPHA5 | EPHA5 isoform 1. (934 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (492 aa) |
| | UNC5C | UNC5C isoform 1. (931 aa) |
| | CAMK2D | CAMK2D isoform 6. (524 aa) |
| | TRPC3 | Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa) |
| | SEMA5A | SEMA5A isoform 1. (1044 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa) |
| | RASA1 | RASA1 isoform 1. (1047 aa) |
| | EFNA5 | EFNA5 isoform 1; Belongs to the ephrin family. (228 aa) |
| | SEMA6A | SEMA6A isoform 1; Belongs to the semaphorin family. (1030 aa) |
| | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] (540 aa) |
| | SLIT3 | SLIT3 isoform 2. (1552 aa) |
| | UNC5A | UNC5A isoform 1. (840 aa) |
| | EPHA7 | EPHA7 isoform 1. (998 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | EPHB4 | EPHB4 isoform 2. (857 aa) |
| | LIMK1 | LIMK1 isoform 2. (468 aa) |
| | CAMK2B | CAMK2B isoform 9. (654 aa) |
| | SEMA3D | SEMA3D isoform 1; Belongs to the semaphorin family. (777 aa) |
| | SEMA3A | SEMA3A isoform 1; Belongs to the semaphorin family. (771 aa) |
| | SEMA3E | SEMA3E isoform 1; Belongs to the semaphorin family. (504 aa) |
| | SEMA3C | Semaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). (754 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1409 aa) |
| | LRRC4 | Leucine rich repeat containing 4. (653 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa) |
| | PLXNA4 | PLXNA4 isoform 2. (1894 aa) |
| | EPHB6 | EPHB6 isoform 3. (999 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (511 aa) |
| | DPYSL2 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (572 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | UNC5D | UNC5D isoform 4. (940 aa) |
| | PTK2 | PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa) |
| | SEMA4D | SEMA4D isoform 10; Belongs to the semaphorin family. (862 aa) |
| | RGS3 | RGS3 isoform 4. (1094 aa) |
| | NTNG2 | NTNG2 isoform 1. (530 aa) |
| | ABL1 | Tyrosine-protein kinase. (948 aa) |
| | PAK3 | Non-specific serine/threonine protein kinase. (559 aa) |
| | TRPC5 | Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa) |
| | PLXNB3 | PLXNB3 isoform 1. (1834 aa) |
| | L1CAM | L1 cell adhesion molecule. (1257 aa) |
| | CAMK2G | CAMK2G isoform 1. (545 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
| | MAPK1 | Mitogen-activated protein kinase 1 isoform X1. (158 aa) |
| | ILK | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa) |
| | PLXNC1 | PLXNC1 isoform 1. (1568 aa) |
| | EPHB2 | EPHB2 isoform 2. (792 aa) |
| | TRPC1 | Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (793 aa) |
