STRINGSTRING
FASLG FASLG CD247 CD247 SH2D1B SH2D1B CR201_G0042089 CR201_G0042089 FCER1G FCER1G CD244 CD244 CD48 CD48 SHC1 SHC1 NRAS NRAS VAV3 VAV3 PIK3R3 PIK3R3 PIK3CD PIK3CD PPP3CB PPP3CB PRF1 PRF1 HRAS HRAS PAK1 PAK1 PTPN6 PTPN6 KLRD1 KLRD1 KLRK1 KLRK1 CR201_G0051047 CR201_G0051047 KLRC1 KLRC1 IFNG IFNG PTPN11 PTPN11 GZMB GZMB SOS2 SOS2 CR201_G0055131 CR201_G0055131 ENSPPYP00000007081 ENSPPYP00000007081 SHC4 SHC4 MAP2K1 MAP2K1 PRKCB PRKCB LAT LAT MAPK3 MAPK3 ITGAL ITGAL PLCG2 PLCG2 ICAM2 ICAM2 GRB2 GRB2 RAC3 RAC3 SHC2 SHC2 VAV1 VAV1 HCST HCST TYROBP TYROBP PRKCG PRKCG CR201_G0053791 CR201_G0053791 LOC100936383 LOC100936383 ENSPPYP00000011640 ENSPPYP00000011640 LOC100437371 LOC100437371 ENSPPYP00000011649 ENSPPYP00000011649 MAP2K2 MAP2K2 PLCG1 PLCG1 NFATC2 NFATC2 ITGB2 ITGB2 RAC2 RAC2 BID-2 BID-2 SOS1 SOS1 RAF1 RAF1 PIK3CB PIK3CB SH3BP2 SH3BP2 CASP3 CASP3 PIK3R1 PIK3R1 CSF2 CSF2 LCP2 LCP2 CR201_G0054081 CR201_G0054081 MICB MICB TNF TNF NCR3 NCR3 NCR2 NCR2 FYN FYN IFNGR1 IFNGR1 RAET1E RAET1E CR201_G0003904 CR201_G0003904 LOC100433010 LOC100433010 ULBP1 ULBP1 LOC100434525 LOC100434525 BRAF BRAF PPP3CC PPP3CC TNFRSF10A TNFRSF10A PTK2B PTK2B IFNA8 IFNA8 IFNA2 IFNA2 LOC100433301 LOC100433301 CR201_G0001880 CR201_G0001880 IFNA6 IFNA6 IFNA5 IFNA5 IFNA14 IFNA14 IFNA21 IFNA21 IFNB1 IFNB1 IFNA21-2 IFNA21-2 ARAF ARAF SH2D1A SH2D1A PIK3CA PIK3CA MAPK1 MAPK1 IFNGR2 IFNGR2 NCR1-2 NCR1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
CD247CD247 isoform 2. (165 aa)
SH2D1BSH2D1B isoform 2. (132 aa)
CR201_G0042089FCGR3A isoform 7. (290 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
CD244CD244 isoform 1. (365 aa)
CD48CD48 isoform 1. (259 aa)
SHC1SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
VAV3VAV3 isoform 1. (824 aa)
PIK3R3T0148502 isoform 1. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
PPP3CBSerine/threonine-protein phosphatase. (438 aa)
PRF1PRF1 isoform 2. (555 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
KLRD1KLRD1 isoform 1. (179 aa)
KLRK1KLRK1 isoform 3. (203 aa)
CR201_G0051047T0180641 isoform 1. (274 aa)
KLRC1NKG2-A/NKG2-B type II integral membrane protein isoform X1. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
GZMBGZMB isoform 1; Belongs to the peptidase S1 family. (281 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CR201_G0055131IGHV3-21 isoform 1. (132 aa)
ENSPPYP00000007081Immunoglobulin delta heavy chain-like. (117 aa)
SHC4SHC4 isoform 1. (612 aa)
MAP2K1MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LATLAT isoform 2. (233 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
ITGALITGAL isoform 1; Belongs to the integrin alpha chain family. (1131 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa)
ICAM2ICAM2 isoform 4. (275 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa)
RAC3RAC3 isoform 1. (192 aa)
SHC2SHC2 isoform 1. (425 aa)
VAV1VAV1 isoform 2. (829 aa)
HCSTHematopoietic cell signal transducer. (93 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (692 aa)
CR201_G0053791KIR3DX1 isoform 1. (365 aa)
LOC100936383Killer cell immunoglobulin-like receptor 3DL3 isoform X3. (475 aa)
ENSPPYP00000011640Killer cell immunoglobulin-like receptor 3DL1 isoform X1. (444 aa)
LOC100437371Killer cell immunoglobulin-like receptor 2DL3 isoform X1. (349 aa)
ENSPPYP00000011649LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 3DL2. (174 aa)
MAP2K2MAP2K2 isoform 6. (213 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
ITGB2Integrin beta. (768 aa)
RAC2Rac family small GTPase 2. (192 aa)
BID-2BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (227 aa)
SOS1SOS1 isoform 2. (1290 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] (648 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SH3BP2SH3BP2 isoform 3. (563 aa)
CASP3CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
CSF2Colony stimulating factor 2. (144 aa)
LCP2LCP2 isoform 3. (534 aa)
CR201_G0054081MICB isoform 1. (360 aa)
MICBMICA isoform 1. (383 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
NCR3Natural cytotoxicity triggering receptor 3. (177 aa)
NCR2NCR2 isoform 1. (258 aa)
FYNTyrosine-protein kinase. (537 aa)
IFNGR1IFNGR1 isoform 1. (489 aa)
RAET1ERAET1E isoform 1. (263 aa)
CR201_G0003904RAET1G isoform 1. (252 aa)
LOC100433010MHC_I-like_Ag-recog domain-containing protein. (243 aa)
ULBP1UL16-binding protein 1 isoform X1. (244 aa)
LOC100434525RAET1L isoform 1. (246 aa)
BRAFBRAF isoform 1. (765 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
TNFRSF10ATNFRSF10A isoform 1. (468 aa)
PTK2BPTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
IFNA8IFNA5 isoform 1. (189 aa)
IFNA2Interferon alpha 2. (188 aa)
LOC100433301IFNA13 isoform 1. (189 aa)
CR201_G0001880IFNA1 isoform 1. (189 aa)
IFNA6IFNA6 isoform 1. (189 aa)
IFNA5IFNA8 isoform 1. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
IFNA21Interferon alpha 21. (189 aa)
IFNB1Interferon beta 1. (187 aa)
IFNA21-2Interferon alpha-21. (153 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
IFNGR2IFNGR2 isoform 1. (197 aa)
NCR1-2Natural cytotoxicity triggering receptor 1 isoform X1. (174 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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