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| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PSEN2 | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (448 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (401 aa) |
| | FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | SHC1 | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa) |
| | NGF | NGF isoform 1; Belongs to the NGF-beta family. (294 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | SORT1 | Sortilin. (789 aa) |
| | JUN | JUN isoform 1; Belongs to the bZIP family. (334 aa) |
| | PIK3R3 | T0148502 isoform 1. (461 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (735 aa) |
| | CDC42 | Cell division cycle 42. (191 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | CALML5 | Calmodulin like 5. (146 aa) |
| | CALML3 | CALML3 isoform 1; Belongs to the calmodulin family. (149 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | BDNF | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa) |
| | IRAK4 | IRAK4 isoform 6. (438 aa) |
| | IRAK3 | IRAK3 isoform 1. (560 aa) |
| | RAP1B | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (508 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (801 aa) |
| | SH2B3 | SH2B3 isoform 1. (567 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa) |
| | NFKBIA | NFKBIA isoform 1. (317 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional act [...] (896 aa) |
| | SHC4 | SHC4 isoform 1. (612 aa) |
| | MAP2K1 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa) |
| | MAP2K5 | MAP2K5 isoform 1; Belongs to the protein kinase superfamily. (448 aa) |
| | CALML4 | LOW QUALITY PROTEIN: calmodulin-like protein 4. (196 aa) |
| | NTRK3 | Tyrosine-protein kinase receptor. (839 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | CRK | CRK isoform 1. (204 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (657 aa) |
| | GRB2 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa) |
| | ARHGDIA | ARHGDIA isoform 3. (204 aa) |
| | NGFR | NGFR isoform 1. (407 aa) |
| | BCL2 | BCL2 isoform 1. (238 aa) |
| | SHC2 | SHC2 isoform 1. (425 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | NFKBIB | NFKBIB isoform 6. (354 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | NTF4 | Neurotrophin 4. (210 aa) |
| | ZNF274 | Zinc finger protein 274. (654 aa) |
| | MAP2K2 | MAP2K2 isoform 6. (213 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa) |
| | ATF4 | ATF4 isoform 1. (352 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (351 aa) |
| | SOS1 | SOS1 isoform 2. (1290 aa) |
| | KIDINS220 | KIDINS220 isoform 8. (1733 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] (648 aa) |
| | IRAK2 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (625 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | CAMK2D | CAMK2D isoform 6. (524 aa) |
| | GAB1 | GAB1 isoform 1. (724 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1505 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa) |
| | CAMK4 | CAMK4 isoform 2; Belongs to the protein kinase superfamily. (615 aa) |
| | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] (540 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | NFKBIE | NFKBIE isoform 1. (361 aa) |
| | FOXO3 | FOXO3 isoform 1. (672 aa) |
| | MAP3K5 | MAP3K5 isoform 1. (1327 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (809 aa) |
| | CAMK2B | CAMK2B isoform 9. (654 aa) |
| | BRAF | BRAF isoform 1. (765 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) |
| | LOC100455662 | Calmodulin-alpha-like. (149 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | RAPGEF1 | RAPGEF1 isoform 1. (1260 aa) |
| | ABL1 | Tyrosine-protein kinase. (948 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | MAGED1 | MAGE family member D1. (778 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (682 aa) |
| | CAMK2G | CAMK2G isoform 1. (545 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
| | MAPK1 | Mitogen-activated protein kinase 1 isoform X1. (158 aa) |
| | ARHGDIG | ARHGDIG isoform 1. (217 aa) |
| | ENSPPYP00000024179 | 14-3-3 protein epsilon-like isoform X1. (173 aa) |
| | CRKL | CRKL isoform 1. (251 aa) |
