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AKT3 AKT3 ADORA1 ADORA1 PTGS2 PTGS2 NPR1 NPR1 TSHB TSHB GNAI3 GNAI3 PRKACB PRKACB PTGER3 PTGER3 PIK3R3 PIK3R3 NPPA NPPA PIK3CD PIK3CD PRKG1 PRKG1 ADRB1 ADRB1 INS-IGF2 INS-IGF2 PLAAT2 PLAAT2 PDE3B PDE3B PLAAT3 PLAAT3 ADCY6 ADCY6 ADCY4 ADCY4 PLIN1 PLIN1 ADCY9 ADCY9 ADCY7 ADCY7 AKT2 AKT2 LIPE LIPE GNAS GNAS MGLL MGLL GNAI2 GNAI2 ABHD5 ABHD5 PIK3CB PIK3CB PRKG2 PRKG2 NPY1R NPY1R PIK3R1 PIK3R1 ADRB2 ADRB2 CGA CGA ADCY1 ADCY1 NPY NPY GNAI1 GNAI1 ADRB3 ADRB3 FABP9 FABP9 FABP4 FABP4 ADCY8 ADCY8 AQP7 AQP7 PRKACG PRKACG IRS4 IRS4 PIK3CA PIK3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (326 aa)
PTGS2PTGS2 isoform 1. (604 aa)
NPR1Guanylate cyclase. (1054 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
PRKACBPRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa)
PTGER3Prostaglandin E receptor 3. (390 aa)
PIK3R3T0148502 isoform 1. (461 aa)
NPPANatriuretic peptide A. (159 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
PRKG1PRKG1 isoform 4; Belongs to the protein kinase superfamily. (251 aa)
ADRB1ADRB1 isoform 1. (345 aa)
INS-IGF2INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
PLAAT2HRASLS2 isoform 1. (162 aa)
PDE3BPhosphodiesterase. (1115 aa)
PLAAT3Phospholipase A and acyltransferase 3; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing th [...] (89 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
ADCY9ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LIPELIPE isoform 2. (1068 aa)
GNASGNAS isoform 2. (1037 aa)
MGLLMonoglyceride lipase. (313 aa)
GNAI2GNAI2 isoform 1. (303 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl- lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of [...] (349 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (116 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa)
NPYNPY isoform 1. (97 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa)
ADRB3ADRB3 isoform 1. (408 aa)
FABP9FABP9 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
AQP7AQP7 isoform 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (198 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
IRS4Insulin receptor substrate 4. (1262 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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