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CHRM3 CHRM3 KCNK2 KCNK2 ATP1B1 ATP1B1 ATP1A4 ATP1A4 ATP1A2 ATP1A2 KCNJ10 KCNJ10 GNAI3 GNAI3 PRKACB PRKACB SLC9A1 SLC9A1 CALML6 CALML6 CALML5 CALML5 CALML3 CALML3 PLCB3 PLCB3 CCKBR CCKBR KCNJ1 KCNJ1 ITPR2 ITPR2 ADCY6 ADCY6 ATP4B ATP4B ADCY4 ADCY4 KCNK10 KCNK10 CALM1 CALM1 CALML4 CALML4 ADCY9 ADCY9 PRKCB PRKCB ADCY7 ADCY7 MYLK3 MYLK3 ATP1B2 ATP1B2 GAST GAST KCNJ16 KCNJ16 KCNJ2 KCNJ2 SSTR2 SSTR2 ACTG1 ACTG1 PRKCG PRKCG PLCB1 PLCB1 GNAS GNAS KCNE2 KCNE2 MYLK MYLK ITPR1 ITPR1 GNAI2 GNAI2 ATP1B3 ATP1B3 SST SST CAMK2D CAMK2D CAMK2A CAMK2A HRH2 HRH2 MYLK4 MYLK4 ITPR3 ITPR3 EZR EZR ACTB ACTB ADCY1 ADCY1 CAMK2B CAMK2B GNAI1 GNAI1 CFTR CFTR SLC4A2 SLC4A2 LOC100455662 LOC100455662 CA2 CA2 SLC26A7 SLC26A7 ADCY8 ADCY8 PRKACG PRKACG GNAQ GNAQ ATP1B4 ATP1B4 CAMK2G CAMK2G PLCB4 PLCB4
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1000 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1020 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
PRKACBPRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
CALML6Calmodulin like 6. (181 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3CALML3 isoform 1; Belongs to the calmodulin family. (149 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa)
CCKBRCCKBR isoform 1; Belongs to the G-protein coupled receptor 1 family. (447 aa)
KCNJ1KCNJ1 isoform 1. (372 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (291 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
KCNK10Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (543 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (196 aa)
ADCY9ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
MYLK3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (819 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
GASTGAST isoform 1. (102 aa)
KCNJ16KCNJ16 isoform 1. (418 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ACTG1ACTG1 isoform 10. (375 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (692 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
GNASGNAS isoform 2. (1037 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
MYLKMYLK isoform 5. (1913 aa)
ITPR1ITPR1 isoform 3. (2769 aa)
GNAI2GNAI2 isoform 1. (303 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
SSTSST isoform 1. (116 aa)
CAMK2DCAMK2D isoform 6. (524 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] (540 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
MYLK4MYLK4 isoform 1; Belongs to the protein kinase superfamily. (388 aa)
ITPR3ITPR3 isoform 1. (2641 aa)
EZREZR isoform 1. (586 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa)
CAMK2BCAMK2B isoform 9. (654 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
SLC4A2Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution. (1239 aa)
LOC100455662Calmodulin-alpha-like. (149 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
SLC26A7Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion (By similarity); Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (656 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNAQG protein subunit alpha q. (359 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (250 aa)
CAMK2GCAMK2G isoform 1. (545 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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