Your Input: | |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) |
| | FCGR2B | FCGR2B isoform 1. (303 aa) |
| | HSPA6 | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa) |
| | SLAMF1 | SLAMF1 isoform 1. (335 aa) |
| | ADAR | ADAR isoform 1. (1226 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | JUN | JUN isoform 1; Belongs to the bZIP family. (334 aa) |
| | PIK3R3 | T0148502 isoform 1. (461 aa) |
| | CASP9 | CASP9 isoform 2; Belongs to the peptidase C14A family. (421 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa) |
| | IL2RA | Interleukin 2 receptor subunit alpha. (272 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | CHUK | CHUK isoform 1. (746 aa) |
| | IRF7 | IRF7 isoform 12. (396 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (173 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | CD3E | CD3E isoform 2. (198 aa) |
| | CD3D | CD3D isoform 1. (171 aa) |
| | CD3G | CD3G isoform 1. (182 aa) |
| | HSPA8 | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (646 aa) |
| | CCND2 | CCND2 isoform 1; Belongs to the cyclin family. (289 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | IRAK4 | IRAK4 isoform 6. (438 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | CDK4 | CDK4 isoform 2; Belongs to the protein kinase superfamily. (317 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | OAS1 | OAS1 isoform 2. (457 aa) |
| | OAS3 | OAS3 isoform 1. (1087 aa) |
| | OAS2 | OAS2 isoform 1. (563 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer. (147 aa) |
| | IRF9 | Interferon regulatory factor 9. (392 aa) |
| | NFKBIA | NFKBIA isoform 1. (317 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | EIF2AK4 | EIF2AK4 isoform 2. (1573 aa) |
| | CSNK2A2 | CSNK2A2 isoform 1; Belongs to the protein kinase superfamily. (327 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | STAT3 | Signal transducer and activator of transcription. (772 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | STAT5B | Signal transducer and activator of transcription. (788 aa) |
| | BCL2 | BCL2 isoform 1. (238 aa) |
| | CLEC4M | CD209 isoform 4. (306 aa) |
| | CCNE1 | CCNE1 isoform 1; Belongs to the cyclin family. (410 aa) |
| | NFKBIB | NFKBIB isoform 6. (354 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | BBC3 | BBC3 isoform 5. (193 aa) |
| | MAVS | MAVS isoform 2. (539 aa) |
| | CSNK2A1 | CSNK2A1 isoform 1; Belongs to the protein kinase superfamily. (391 aa) |
| | BCL2L1 | BCL2L1 isoform 2. (233 aa) |
| | MX2 | MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa) |
| | MX1 | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity. (662 aa) |
| | BID-2 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (227 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (273 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | EIF2AK3 | EIF2AK3 isoform 1. (1116 aa) |
| | IFIH1 | IFIH1 isoform 1. (1024 aa) |
| | STAT1 | Signal transducer and activator of transcription. (766 aa) |
| | CASP8 | CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa) |
| | TLR2 | Toll-like receptor. (783 aa) |
| | CASP3 | CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | CSNK2B | Casein kinase II subunit beta. (215 aa) |
| | HSPA1L | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa) |
| | HSPA1A | Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (641 aa) |
| | ENSPPYP00000018466 | Cytochrome c-like. (105 aa) |
| | CCND3 | CCND3 isoform 1; Belongs to the cyclin family. (292 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa) |
| | TNFAIP3 | TNFAIP3 isoform 1. (790 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | IL6 | IL6 isoform 2. (212 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) |
| | EIF3H | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa) |
| | DDX58 | DDX58 isoform 2. (875 aa) |
| | IFNA8 | IFNA5 isoform 1. (189 aa) |
| | IFNA2 | Interferon alpha 2. (188 aa) |
| | LOC100433301 | IFNA13 isoform 1. (189 aa) |
| | CR201_G0001880 | IFNA1 isoform 1. (189 aa) |
| | IFNA6 | IFNA6 isoform 1. (189 aa) |
| | IFNA5 | IFNA8 isoform 1. (189 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | IFNA21 | Interferon alpha 21. (189 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | ENSPPYP00000021735 | Cytochrome c-like. (38 aa) |
| | TLR4 | TLR4 isoform 1; Belongs to the Toll-like receptor family. (804 aa) |
| | IFNA21-2 | Interferon alpha-21. (153 aa) |
| | RACK1 | RACK1 isoform 13. (372 aa) |
| | MSN | MSN isoform 6. (577 aa) |
| | IL2RG | IL2RG isoform 2. (369 aa) |
| | RAB9B | Ras-related protein Rab-9B; Involved in the transport of proteins between the endosomes and the trans Golgi network. (201 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (682 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
