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| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ELK4 | ETS transcription factor ELK4. (431 aa) |
| | FDPS | FDPS isoform 12; Belongs to the FPP/GGPP synthase family. (437 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | PRKACB | PRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | JUN | JUN isoform 1; Belongs to the bZIP family. (334 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | PIK3R3 | T0148502 isoform 1. (461 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | SLC2A1 | SLC2A1 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa) |
| | E2F2 | E2F2 isoform 1. (437 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa) |
| | IL2RA | Interleukin 2 receptor subunit alpha. (272 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (438 aa) |
| | EGR2 | Early growth response 2. (476 aa) |
| | PTEN | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | CHUK | CHUK isoform 1. (746 aa) |
| | NFKB2 | NFKB2 isoform 4. (868 aa) |
| | BUB3 | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] (328 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (173 aa) |
| | FOSL1 | FOSL1 isoform 2. (270 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | SPI1 | Spi-1 proto-oncogene. (270 aa) |
| | MMP7 | MMP7 isoform 1. (267 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa) |
| | CD3E | CD3E isoform 2. (198 aa) |
| | CD3D | CD3D isoform 1. (171 aa) |
| | CD3G | CD3G isoform 1. (182 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (441 aa) |
| | CCND2 | CCND2 isoform 1; Belongs to the cyclin family. (289 aa) |
| | TNFRSF1A | TNFRSF1A isoform 2. (454 aa) |
| | CD4 | CD4 isoform 2. (414 aa) |
| | ADCY6 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa) |
| | ESPL1 | ESPL1 isoform 1. (2075 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | CDK4 | CDK4 isoform 2; Belongs to the protein kinase superfamily. (317 aa) |
| | NFYB | NFYB isoform 1. (207 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (755 aa) |
| | RAN | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (236 aa) |
| | CCNA1 | CCNA1 isoform 3; Belongs to the cyclin family. (464 aa) |
| | RB1 | RB1 isoform 1. (928 aa) |
| | ADCY4 | Adenylate cyclase type 4 isoform X1. (1077 aa) |
| | NFATC4 | NFATC4 isoform 21. (868 aa) |
| | NFKBIA | NFKBIA isoform 1. (317 aa) |
| | TBPL2 | TATA-box binding protein like 2. (375 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1050 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa) |
| | CCNB2 | CCNB2 isoform 1; Belongs to the cyclin family. (398 aa) |
| | TLN2 | TLN2 isoform 1. (2542 aa) |
| | MAP2K1 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | CRTC3 | CRTC3 isoform 4. (576 aa) |
| | CREBBP | CREBBP isoform 1. (2328 aa) |
| | ADCY9 | ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | ITGAL | ITGAL isoform 1; Belongs to the integrin alpha chain family. (1131 aa) |
| | ADCY7 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1068 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (782 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | STAT5B | Signal transducer and activator of transcription. (788 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (657 aa) |
| | CDC27 | CDC27 isoform 1. (824 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | RANBP3 | Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). (499 aa) |
| | CALR | Calreticulin. (417 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (634 aa) |
| | CCNE1 | CCNE1 isoform 1; Belongs to the cyclin family. (410 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa) |
| | RELB | RELB isoform 1. (581 aa) |
| | ZFP36 | ZFP36 isoform 1. (216 aa) |
| | MAP2K2 | MAP2K2 isoform 6. (213 aa) |
| | BCL2L1 | BCL2L1 isoform 2. (233 aa) |
| | E2F1 | E2F1 isoform 1. (361 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa) |
| | ITGB2 | Integrin beta. (768 aa) |
| | RANBP1 | RANBP1 isoform 6. (201 aa) |
| | CHEK2 | CHEK2 isoform 5. (520 aa) |
| | ATF4 | ATF4 isoform 1. (352 aa) |
| | EP300 | EP300 isoform 1. (2380 aa) |
| | TNFRSF13C | TNFRSF13C isoform 1. (168 aa) |
| | TSPO | Translocator protein. (169 aa) |
| | IL1R2 | IL1R2 isoform 2. (390 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (569 aa) |
| | ANAPC1 | ANAPC1 isoform 2. (1855 aa) |
| | XPO1 | XPO1 isoform 9. (1034 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | CREB1 | CREB1 isoform 1. (341 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | ATR | ATR isoform 1; Belongs to the PI3/PI4-kinase family. (2636 aa) |
| | DLG1 | DLG1 isoform 5; Belongs to the MAGUK family. (922 aa) |
| | MSX1 | MSX1 isoform 1. (261 aa) |
| | ZCCHC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (1106 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | MAD2L1 | MAD2L1 isoform 1. (300 aa) |
| | CCNA2 | CCNA2 isoform 1; Belongs to the cyclin family. (432 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa) |
| | SLC25A31 | SLC25A31 isoform 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (253 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1505 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa) |
| | CSF2 | Colony stimulating factor 2. (144 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | PTTG1 | PTTG1 regulator of sister chromatid separation, securin. (202 aa) |
| | MSX2 | MSX2 isoform 1. (269 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | E2F3 | E2F3 isoform 2. (427 aa) |
| | Poab-F | MHC class I protein; Belongs to the MHC class I family. (346 aa) |
| | HLA-A | Popy Class I histocompatibility antigen, A-1 alpha chain. (365 aa) |
| | HLA-E | HLA-E isoform 1; Belongs to the MHC class I family. (387 aa) |
| | LTA | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa) |
| | TNF | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa) |
| | ATF6B | ATF6B isoform 2. (721 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (266 aa) |
| | ENSPPYP00000018441 | HLA class II histocompatibility antigen, DQ alpha 2 chain. (190 aa) |
| | CR201_G0016196 | HLA-DQB1 isoform 5. (304 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | TSPO2 | TSPO2 isoform 1. (170 aa) |
| | CCND3 | CCND3 isoform 1; Belongs to the cyclin family. (292 aa) |
| | SRF | Serum response factor. (508 aa) |
| | TBPL1 | TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). (163 aa) |
| | TBP | TBP isoform 3. (327 aa) |
| | CR201_G0055889 | Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa) |
| | ENSPPYP00000019293 | HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa) |
| | ENSPPYP00000019298 | HLA class II histocompatibility antigen, DQ alpha 2 chain. (63 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain. (272 aa) |
| | LOC100448477 | HLA-DMB isoform 5. (263 aa) |
| | HLA-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (261 aa) |
| | CR201_G0016219 | HLA-DPB1 isoform 1. (283 aa) |
| | LOC100460187 | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | CR201_G0016218-2 | HLA-DPA1 isoform 3. (239 aa) |
| | CR201_G0055693 | HLA-B isoform 1; Belongs to the MHC class I family. (362 aa) |
| | CR201_G0042422-3 | HLA-G isoform 6. (259 aa) |
| | ENSPPYP00000019353 | HLA class I histocompatibility antigen, alpha chain G isoform X1. (66 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3830 aa) |
| | ADCY1 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | IL6 | IL6 isoform 2. (212 aa) |
| | CREB3L2 | Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (520 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (511 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (283 aa) |
| | MYC | MYC isoform 1. (453 aa) |
| | ADCY8 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | TLN1 | TLN1 isoform 1. (2541 aa) |
| | ENSPPYP00000021457 | Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. (72 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (137 aa) |
| | PRKACG | Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa) |
| | CDC26 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | IL2RG | IL2RG isoform 2. (369 aa) |
| | SLC25A5 | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). (530 aa) |
| | XIAP | XIAP isoform 2. (513 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
| | CR201_G0042434 | HLA-A isoform 3; Belongs to the MHC class I family. (362 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | MAPK1 | Mitogen-activated protein kinase 1 isoform X1. (158 aa) |
| | ELK1 | ETS transcription factor ELK1. (429 aa) |
