STRINGSTRING
AKT3 AKT3 RXRG RXRG NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 E2F2 E2F2 CASP9 CASP9 PIK3CD PIK3CD HRAS HRAS CCND1 CCND1 BAD BAD DDB2 DDB2 CDK4 CDK4 RB1 RB1 BAK1 BAK1 SOS2 SOS2 MAP2K1 MAP2K1 PRKCB PRKCB MAPK3 MAPK3 PLCG2 PLCG2 TP53 TP53 STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B ERBB2 ERBB2 GRB2 GRB2 GADD45B GADD45B AKT2 AKT2 PRKCG PRKCG MAP2K2 MAP2K2 E2F1 E2F1 PLCG1 PLCG1 STK4 STK4 TGFA TGFA EML4 EML4 SOS1 SOS1 ALK ALK RAF1 RAF1 FHIT FHIT RASSF1 RASSF1 RARB RARB PIK3CB PIK3CB EGF EGF PIK3R1 PIK3R1 POLK POLK E2F3 E2F3 CDKN1A CDKN1A FOXO3 FOXO3 RXRB RXRB EGFR EGFR CDK6 CDK6 HGF HGF MET MET BRAF BRAF GADD45G GADD45G ARAF ARAF PIK3CA PIK3CA MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (462 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3T0148502 isoform 1. (461 aa)
E2F2E2F2 isoform 1. (437 aa)
CASP9CASP9 isoform 2; Belongs to the peptidase C14A family. (421 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (173 aa)
BADBCL2 associated agonist of cell death. (168 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
CDK4CDK4 isoform 2; Belongs to the protein kinase superfamily. (317 aa)
RB1RB1 isoform 1. (928 aa)
BAK1Bcl-2 homologous antagonist/killer. (147 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAP2K1MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (788 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa)
GADD45BGADD45B isoform 5. (148 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (692 aa)
MAP2K2MAP2K2 isoform 6. (213 aa)
E2F1E2F1 isoform 1. (361 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
STK4STK4 isoform 1. (474 aa)
TGFATGFA isoform 5. (159 aa)
EML4EML4 isoform 2. (981 aa)
SOS1SOS1 isoform 2. (1290 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] (648 aa)
FHITBis(5'-adenosyl)-triphosphatase. (147 aa)
RASSF1RASSF1 isoform 4. (304 aa)
RARBRARB isoform 2. (526 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1177 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
POLKPOLK isoform 1. (892 aa)
E2F3E2F3 isoform 2. (427 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
FOXO3FOXO3 isoform 1. (672 aa)
RXRBRetinoid X receptor beta. (536 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1409 aa)
BRAFBRAF isoform 1. (765 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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