node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMBN | BGLAP | ENSP00000313809 | ENSP00000357255 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.435 |
AMBN | DMP1 | ENSP00000313809 | ENSP00000340935 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | 0.660 |
AMBN | DSPP | ENSP00000313809 | ENSP00000498766 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | 0.842 |
AMBN | ENAM | ENSP00000313809 | ENSP00000379383 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.999 |
AMBN | IBSP | ENSP00000313809 | ENSP00000226284 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.819 |
AMBN | MMP20 | ENSP00000313809 | ENSP00000260228 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.892 |
BGLAP | AMBN | ENSP00000357255 | ENSP00000313809 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | 0.435 |
BGLAP | DMP1 | ENSP00000357255 | ENSP00000340935 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | 0.788 |
BGLAP | DSPP | ENSP00000357255 | ENSP00000498766 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | 0.834 |
BGLAP | IBSP | ENSP00000357255 | ENSP00000226284 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.971 |
DMP1 | AMBN | ENSP00000340935 | ENSP00000313809 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | 0.660 |
DMP1 | BGLAP | ENSP00000340935 | ENSP00000357255 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.788 |
DMP1 | DSPP | ENSP00000340935 | ENSP00000498766 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | 0.982 |
DMP1 | ENAM | ENSP00000340935 | ENSP00000379383 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.794 |
DMP1 | IBSP | ENSP00000340935 | ENSP00000226284 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.969 |
DMP1 | MMP20 | ENSP00000340935 | ENSP00000260228 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.591 |
DSPP | AMBN | ENSP00000498766 | ENSP00000313809 | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | 0.842 |
DSPP | BGLAP | ENSP00000498766 | ENSP00000357255 | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.834 |
DSPP | DMP1 | ENSP00000498766 | ENSP00000340935 | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. | 0.982 |
DSPP | ENAM | ENSP00000498766 | ENSP00000379383 | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.899 |