(32 nodes) Cytoplasmic ribosomal proteins network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPL35	60S ribosomal protein L35; Component of the large ribosomal subunit. (123 aa)
	RPL8	60S ribosomal protein L8; Component of the large ribosomal subunit. (257 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
	RPL37	60S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (97 aa)
	RPL29	60S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (159 aa)
	RPS23	40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
	RPL13	Ribosomal protein L13. (211 aa)
	RPL15	Ribosomal protein L15. (204 aa)
	RPS2	Ribosomal protein S2. (293 aa)
	RPS21	Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
	RPL27A	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. (148 aa)
	RPL12	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA. (165 aa)
	RPS16	Ribosomal protein S16. (152 aa)
	RPS9	Ribosomal protein S9. (194 aa)
	RPL13A	60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppre [...] (203 aa)
	RPL34	60S ribosomal protein L34; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL34 family. (117 aa)
	RPS29	Ribosomal protein S29. (67 aa)
	RPL14	60S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family. (215 aa)
	RPS8	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
	RPS14	Ribosomal protein S14. (151 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Dengue virus [...] (300 aa)
	RPL23	Ribosomal protein L23. (140 aa)
	RPLP2	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis. (115 aa)
	FAU	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. (133 aa)
	RPS13	Ribosomal protein S13. (151 aa)
	RPLP0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
	RPL28	60S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family. (170 aa)
	RPL26	60S ribosomal protein L26; Component of the large ribosomal subunit. (145 aa)
	RPS15	Ribosomal protein S15. (152 aa)
	RPL9	Ribosomal protein L9. (192 aa)
	RPL35A	60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. (110 aa)
	RPS17	Ribosomal protein S17. (135 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAU	RPL12	ENSP00000431822	ENSP00000354739	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA.	0.999
FAU	RPL13	ENSP00000431822	ENSP00000307889	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein L13.	0.999
FAU	RPL13A	ENSP00000431822	ENSP00000375730	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppre [...]	0.999
FAU	RPL14	ENSP00000431822	ENSP00000379506	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family.	0.999
FAU	RPL15	ENSP00000431822	ENSP00000309334	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein L15.	0.999
FAU	RPL23	ENSP00000431822	ENSP00000420311	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein L23.	0.999
FAU	RPL26	ENSP00000431822	ENSP00000463784	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L26; Component of the large ribosomal subunit.	0.999
FAU	RPL27A	ENSP00000431822	ENSP00000346015	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.	0.999
FAU	RPL28	ENSP00000431822	ENSP00000452763	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family.	0.999
FAU	RPL29	ENSP00000431822	ENSP00000294189	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family.	0.999
FAU	RPL34	ENSP00000431822	ENSP00000378163	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L34; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL34 family.	0.999
FAU	RPL35	ENSP00000431822	ENSP00000259469	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L35; Component of the large ribosomal subunit.	0.999
FAU	RPL35A	ENSP00000431822	ENSP00000495672	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.	0.999
FAU	RPL37	ENSP00000431822	ENSP00000274242	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.	0.999
FAU	RPL8	ENSP00000431822	ENSP00000262584	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S ribosomal protein L8; Component of the large ribosomal subunit.	0.999
FAU	RPL9	ENSP00000431822	ENSP00000494697	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein L9.	0.999
FAU	RPLP0	ENSP00000431822	ENSP00000449328	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.999
FAU	RPLP2	ENSP00000431822	ENSP00000431240	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis.	0.999
FAU	RPS13	ENSP00000431822	ENSP00000435777	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein S13.	0.999
FAU	RPS14	ENSP00000431822	ENSP00000385958	Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.	Ribosomal protein S14.	0.999