node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEP70 | FCRL5 | ENSP00000264982 | ENSP00000354691 | Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle. | Fc receptor-like protein 5; May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. | 0.526 |
CEP70 | GPRC5D | ENSP00000264982 | ENSP00000228887 | Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle. | G protein-coupled receptor class C group 5 member D; Belongs to the G-protein coupled receptor 3 family. | 0.705 |
FCER2 | FCMR | ENSP00000264072 | ENSP00000356058 | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | 0.445 |
FCER2 | FCRLA | ENSP00000264072 | ENSP00000356936 | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). | Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis. | 0.628 |
FCER2 | MS4A1 | ENSP00000264072 | ENSP00000433277 | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). | B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. | 0.682 |
FCER2 | RBMS1 | ENSP00000264072 | ENSP00000294904 | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). | RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. | 0.639 |
FCER2 | VPREB3 | ENSP00000264072 | ENSP00000248948 | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). | Pre-B lymphocyte protein 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells; Belongs to the immunoglobulin superfamily. | 0.529 |
FCMR | FCER2 | ENSP00000356058 | ENSP00000264072 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). | 0.445 |
FCMR | FCRL1 | ENSP00000356058 | ENSP00000357158 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | 0.408 |
FCMR | FCRL3 | ENSP00000356058 | ENSP00000357169 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | Fc receptor-like protein 3; Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation- induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenoty [...] | 0.473 |
FCMR | FCRLA | ENSP00000356058 | ENSP00000356936 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis. | 0.645 |
FCMR | MS4A1 | ENSP00000356058 | ENSP00000433277 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. | 0.582 |
FCMR | VPREB3 | ENSP00000356058 | ENSP00000248948 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | Pre-B lymphocyte protein 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells; Belongs to the immunoglobulin superfamily. | 0.615 |
FCRL1 | FCMR | ENSP00000357158 | ENSP00000356058 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | 0.408 |
FCRL1 | FCRL2 | ENSP00000357158 | ENSP00000355157 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | Fc receptor-like protein 2; May have an regulatory role in normal and neoplastic B cell development. | 0.663 |
FCRL1 | FCRL3 | ENSP00000357158 | ENSP00000357169 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | Fc receptor-like protein 3; Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation- induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenoty [...] | 0.660 |
FCRL1 | FCRL5 | ENSP00000357158 | ENSP00000354691 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | Fc receptor-like protein 5; May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. | 0.568 |
FCRL1 | FCRLA | ENSP00000357158 | ENSP00000356936 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis. | 0.565 |
FCRL1 | MS4A1 | ENSP00000357158 | ENSP00000433277 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. | 0.826 |
FCRL1 | NIBAN3 | ENSP00000357158 | ENSP00000335040 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. | Niban apoptosis regulator 3; Belongs to the Niban family. | 0.421 |