node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHNAK | AHNAK2 | ENSP00000367263 | ENSP00000353114 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | AHNAK nucleoprotein 2. | 0.944 |
AHNAK | ANXA2 | ENSP00000367263 | ENSP00000346032 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.999 |
AHNAK | ANXA6 | ENSP00000367263 | ENSP00000346550 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | 0.633 |
AHNAK | CAV3 | ENSP00000367263 | ENSP00000341940 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae ; Belongs to the caveolin family. | 0.589 |
AHNAK | DYSF | ENSP00000367263 | ENSP00000386881 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.982 |
AHNAK | S100A10 | ENSP00000367263 | ENSP00000357801 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.999 |
AHNAK | S100A11 | ENSP00000367263 | ENSP00000271638 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family. | 0.476 |
AHNAK | S100A6 | ENSP00000367263 | ENSP00000357709 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. | 0.507 |
AHNAK | TRIM72 | ENSP00000367263 | ENSP00000312675 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] | 0.678 |
AHNAK2 | AHNAK | ENSP00000353114 | ENSP00000367263 | AHNAK nucleoprotein 2. | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | 0.944 |
AHNAK2 | ANXA2 | ENSP00000353114 | ENSP00000346032 | AHNAK nucleoprotein 2. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.971 |
AHNAK2 | DYSF | ENSP00000353114 | ENSP00000386881 | AHNAK nucleoprotein 2. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.501 |
AHNAK2 | S100A10 | ENSP00000353114 | ENSP00000357801 | AHNAK nucleoprotein 2. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.949 |
ANXA11 | ANXA2 | ENSP00000398610 | ENSP00000346032 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.522 |
ANXA11 | ANXA3 | ENSP00000398610 | ENSP00000264908 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Annexin A3; Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate; Belongs to the annexin family. | 0.634 |
ANXA11 | ANXA6 | ENSP00000398610 | ENSP00000346550 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | 0.456 |
ANXA11 | DYSF | ENSP00000398610 | ENSP00000386881 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.422 |
ANXA11 | S100A10 | ENSP00000398610 | ENSP00000357801 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.472 |
ANXA11 | S100A11 | ENSP00000398610 | ENSP00000271638 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family. | 0.451 |
ANXA11 | S100A6 | ENSP00000398610 | ENSP00000357709 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. | 0.985 |