5 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	S100A11	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family. (105 aa)
	ANXA2	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. (357 aa)
	AHNAK2	AHNAK nucleoprotein 2. (5795 aa)
	S100A10	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. (97 aa)
	AHNAK	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. (5890 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHNAK	AHNAK2	ENSP00000367263	ENSP00000353114	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	AHNAK nucleoprotein 2.	0.944
AHNAK	ANXA2	ENSP00000367263	ENSP00000346032	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	0.999
AHNAK	S100A10	ENSP00000367263	ENSP00000357801	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	0.999
AHNAK	S100A11	ENSP00000367263	ENSP00000271638	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.	0.476
AHNAK2	AHNAK	ENSP00000353114	ENSP00000367263	AHNAK nucleoprotein 2.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.944
AHNAK2	ANXA2	ENSP00000353114	ENSP00000346032	AHNAK nucleoprotein 2.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	0.971
AHNAK2	S100A10	ENSP00000353114	ENSP00000357801	AHNAK nucleoprotein 2.	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	0.949
ANXA2	AHNAK	ENSP00000346032	ENSP00000367263	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.999
ANXA2	AHNAK2	ENSP00000346032	ENSP00000353114	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	AHNAK nucleoprotein 2.	0.971
ANXA2	S100A10	ENSP00000346032	ENSP00000357801	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	0.999
ANXA2	S100A11	ENSP00000346032	ENSP00000271638	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.	0.996
S100A10	AHNAK	ENSP00000357801	ENSP00000367263	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.999
S100A10	AHNAK2	ENSP00000357801	ENSP00000353114	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	AHNAK nucleoprotein 2.	0.949
S100A10	ANXA2	ENSP00000357801	ENSP00000346032	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	0.999
S100A10	S100A11	ENSP00000357801	ENSP00000271638	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.	0.716
S100A11	AHNAK	ENSP00000271638	ENSP00000367263	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.476
S100A11	ANXA2	ENSP00000271638	ENSP00000346032	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	0.996
S100A11	S100A10	ENSP00000271638	ENSP00000357801	Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	0.716