(5 nodes) Defective CHST6 causes MCDC1, and Collagen V binding network (Homo sapiens)

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Your Input:
	PRELP	Prolargin; May anchor basement membranes to the underlying connective tissue. (382 aa)
	ECM2	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness. (699 aa)
	DPT	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). (201 aa)
	OMD	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity). (421 aa)
	OGN	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. (298 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DPT	ECM2	ENSP00000356791	ENSP00000344758	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	0.509
DPT	OGN	ENSP00000356791	ENSP00000364711	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.676
DPT	OMD	ENSP00000356791	ENSP00000364700	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.455
DPT	PRELP	ENSP00000356791	ENSP00000343924	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.777
ECM2	DPT	ENSP00000344758	ENSP00000356791	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	0.509
ECM2	OGN	ENSP00000344758	ENSP00000364711	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.687
ECM2	OMD	ENSP00000344758	ENSP00000364700	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.703
ECM2	PRELP	ENSP00000344758	ENSP00000343924	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.414
OGN	DPT	ENSP00000364711	ENSP00000356791	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	0.676
OGN	ECM2	ENSP00000364711	ENSP00000344758	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	0.687
OGN	OMD	ENSP00000364711	ENSP00000364700	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.946
OGN	PRELP	ENSP00000364711	ENSP00000343924	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.800
OMD	DPT	ENSP00000364700	ENSP00000356791	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	0.455
OMD	ECM2	ENSP00000364700	ENSP00000344758	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	0.703
OMD	OGN	ENSP00000364700	ENSP00000364711	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.946
OMD	PRELP	ENSP00000364700	ENSP00000343924	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.814
PRELP	DPT	ENSP00000343924	ENSP00000356791	Prolargin; May anchor basement membranes to the underlying connective tissue.	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	0.777
PRELP	ECM2	ENSP00000343924	ENSP00000344758	Prolargin; May anchor basement membranes to the underlying connective tissue.	Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.	0.414
PRELP	OGN	ENSP00000343924	ENSP00000364711	Prolargin; May anchor basement membranes to the underlying connective tissue.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.800
PRELP	OMD	ENSP00000343924	ENSP00000364700	Prolargin; May anchor basement membranes to the underlying connective tissue.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.814