(11 nodes) Mostly uncharacterized, incl. Transmembrane protein 88, and Transmembrane protein 178A/B network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FAM189A1	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family. (539 aa)
	PSD2	Pleckstrin and Sec7 domain containing 2. (771 aa)
	TMEM178A	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Belongs to the TMEM178 family. (297 aa)
	FAM171B	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family. (826 aa)
	PTCHD4	Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4- expressing cells; Belongs to the patched family. (846 aa)
	SLC35F3	Putative thiamine transporter SLC35F3; May be a thiamine transporter; Belongs to the SLC35F solute transporter family. (490 aa)
	IER5L	Immediate early response 5 like. (404 aa)
	TMEM130	Transmembrane protein 130. (435 aa)
	TMEM179	Transmembrane protein 179; Belongs to the TMEM179 family. (233 aa)
	TMEM88B	Transmembrane protein 88B. (163 aa)
	TMEM59L	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. (342 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM171B	FAM189A1	ENSP00000304108	ENSP00000261275	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.449
FAM171B	TMEM179	ENSP00000304108	ENSP00000450958	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.	Transmembrane protein 179; Belongs to the TMEM179 family.	0.429
FAM171B	TMEM59L	ENSP00000304108	ENSP00000470879	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.407
FAM171B	TMEM88B	ENSP00000304108	ENSP00000455099	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.	Transmembrane protein 88B.	0.464
FAM189A1	FAM171B	ENSP00000261275	ENSP00000304108	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.	0.449
FAM189A1	TMEM179	ENSP00000261275	ENSP00000450958	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Transmembrane protein 179; Belongs to the TMEM179 family.	0.478
FAM189A1	TMEM59L	ENSP00000261275	ENSP00000470879	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.436
FAM189A1	TMEM88B	ENSP00000261275	ENSP00000455099	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Transmembrane protein 88B.	0.488
IER5L	SLC35F3	ENSP00000361569	ENSP00000355577	Immediate early response 5 like.	Putative thiamine transporter SLC35F3; May be a thiamine transporter; Belongs to the SLC35F solute transporter family.	0.425
PSD2	TMEM59L	ENSP00000274710	ENSP00000470879	Pleckstrin and Sec7 domain containing 2.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.590
PTCHD4	TMEM178A	ENSP00000341914	ENSP00000281961	Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4- expressing cells; Belongs to the patched family.	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Belongs to the TMEM178 family.	0.495
SLC35F3	IER5L	ENSP00000355577	ENSP00000361569	Putative thiamine transporter SLC35F3; May be a thiamine transporter; Belongs to the SLC35F solute transporter family.	Immediate early response 5 like.	0.425
TMEM130	TMEM179	ENSP00000413163	ENSP00000450958	Transmembrane protein 130.	Transmembrane protein 179; Belongs to the TMEM179 family.	0.424
TMEM130	TMEM88B	ENSP00000413163	ENSP00000455099	Transmembrane protein 130.	Transmembrane protein 88B.	0.421
TMEM178A	PTCHD4	ENSP00000281961	ENSP00000341914	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Belongs to the TMEM178 family.	Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4- expressing cells; Belongs to the patched family.	0.495
TMEM178A	TMEM179	ENSP00000281961	ENSP00000450958	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Belongs to the TMEM178 family.	Transmembrane protein 179; Belongs to the TMEM179 family.	0.436
TMEM178A	TMEM59L	ENSP00000281961	ENSP00000470879	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Belongs to the TMEM178 family.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.455
TMEM178A	TMEM88B	ENSP00000281961	ENSP00000455099	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Belongs to the TMEM178 family.	Transmembrane protein 88B.	0.427
TMEM179	FAM171B	ENSP00000450958	ENSP00000304108	Transmembrane protein 179; Belongs to the TMEM179 family.	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.	0.429
TMEM179	FAM189A1	ENSP00000450958	ENSP00000261275	Transmembrane protein 179; Belongs to the TMEM179 family.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.478