STRINGSTRING
GPR83 GPR83 GPR45 GPR45 GPR32 GPR32 GPR26 GPR26 GPR85 GPR85 GPR25 GPR25 GPR27 GPR27 GPR82 GPR82 GPR171 GPR171 GPR162 GPR162 GPR88 GPR88 GPR52 GPR52 GPR150 GPR150 GPR6 GPR6 GPR176 GPR176 GPR101 GPR101
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR83Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor. (423 aa)
GPR45Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function. (372 aa)
GPR32Probable G-protein coupled receptor 32; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (356 aa)
GPR26G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. (337 aa)
GPR85Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
GPR25Probable G-protein coupled receptor 25; Orphan receptor. (361 aa)
GPR27Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. (375 aa)
GPR82Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (336 aa)
GPR171Probable G-protein coupled receptor 171; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (319 aa)
GPR162Probable G-protein coupled receptor 162; Orphan receptor. (588 aa)
GPR88Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. (384 aa)
GPR52G-protein coupled receptor 52; Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation. (361 aa)
GPR150Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (434 aa)
GPR6G-protein coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). (377 aa)
GPR176G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. (515 aa)
GPR101Probable G-protein coupled receptor 101; Orphan receptor. (508 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.