STRINGSTRING
ZNF180 ZNF180 RASIP1 RASIP1 SNX17 SNX17 USHBP1 USHBP1 ARHGAP29 ARHGAP29 MESD MESD CCM2L CCM2L FNDC4 FNDC4 TLNRD1 TLNRD1 PCYOX1L PCYOX1L ADGRF5 ADGRF5 EMCN EMCN AFAP1L1 AFAP1L1 ZMAT4 ZMAT4 SHE SHE HEG1 HEG1 ZNF512 ZNF512 TMC3 TMC3 CLEC14A CLEC14A ITGB1BP1 ITGB1BP1 MAP3K3 MAP3K3 MYCT1 MYCT1 TDRD10 TDRD10 ADGRL4 ADGRL4 TTC22 TTC22 EGFL7 EGFL7 MMRN2 MMRN2 CCM2 CCM2 ESM1 ESM1 KRIT1 KRIT1 C2orf16 C2orf16 CCDC121 CCDC121 EVX1 EVX1 KRTCAP3 KRTCAP3 XKR7 XKR7 ECSCR ECSCR ZNF343 ZNF343 ENSP00000498010 ENSP00000498010
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF180Zinc finger protein 180; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (692 aa)
RASIP1Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras- like proteins. May promote HR [...] (963 aa)
SNX17Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (470 aa)
USHBP1Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1. (703 aa)
ARHGAP29Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. (1261 aa)
MESDLRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By simi [...] (234 aa)
CCM2LCerebral cavernous malformations 2 protein-like; CCM2 like scaffold protein. (433 aa)
FNDC4Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. (234 aa)
TLNRD1Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. (362 aa)
PCYOX1LPrenylcysteine oxidase-like; Probable oxidoreductase. (494 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (1346 aa)
EMCNEndomucin; Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. (261 aa)
AFAP1L1Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. (768 aa)
ZMAT4Zinc finger matrin-type 4. (229 aa)
SHESH2 domain-containing adapter protein E; Src homology 2 domain containing E. (495 aa)
HEG1Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. (1381 aa)
ZNF512Zinc finger protein 512; May be involved in transcriptional regulation. (567 aa)
TMC3Transmembrane channel-like protein 3; Probable ion channel. (1100 aa)
CLEC14AC-type lectin domain containing 14A. (490 aa)
ITGB1BP1Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling [...] (200 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. (657 aa)
MYCT1Myc target protein 1; May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). (235 aa)
TDRD10Tudor domain containing 10. (366 aa)
ADGRL4Adhesion G protein-coupled receptor L4; Endothelial orphan receptor that acts as a key regulator of angiogenesis. (690 aa)
TTC22Tetratricopeptide repeat domain 22. (569 aa)
EGFL7Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet- derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. (273 aa)
MMRN2Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. (949 aa)
CCM2Cerebral cavernous malformations 2 protein; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). (465 aa)
ESM1Endothelial cell-specific molecule 1; Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. (184 aa)
KRIT1Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH- dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and v [...] (736 aa)
C2orf16Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. (1984 aa)
CCDC121Coiled-coil domain containing 121. (440 aa)
EVX1Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. (407 aa)
KRTCAP3Keratinocyte associated protein 3. (240 aa)
XKR7XK-related protein 7; XK related 7. (579 aa)
ECSCREndothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Belongs to the ECSCR family. (205 aa)
ZNF343Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (640 aa)
ENSP00000498010Uncharacterized protein. (708 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.