STRINGSTRING
TRIB2 TRIB2 TEKT2 TEKT2 CCDC113 CCDC113 FAM149B1 FAM149B1 C11orf1 C11orf1 MNS1 MNS1 EFCAB1 EFCAB1 CFAP20 CFAP20 EFCAB6 EFCAB6 TEKT5 TEKT5 CFAP161 CFAP161 TEKT4 TEKT4 ARMC3 ARMC3 CCDC96 CCDC96 TRIB1 TRIB1 C19orf71 C19orf71 ENKUR ENKUR SPAG16 SPAG16 FAM166C FAM166C FAM183A FAM183A PACRG PACRG CFAP52 CFAP52 SPAG8 SPAG8 TEKT1 TEKT1 CFAP77 CFAP77 CFAP126 CFAP126 CFAP45 CFAP45 C1orf189 C1orf189 CFAP206 CFAP206 C1orf194 C1orf194 EFHC1 EFHC1 SPACA9 SPACA9 DNAJC9 DNAJC9 STK40 STK40 SPAG6 SPAG6 C9orf135 C9orf135 C4orf47 C4orf47 TEKT3 TEKT3 TBC1D32 TBC1D32 CFAP53 CFAP53 FAM166B FAM166B C5orf49 C5orf49 MEIG1 MEIG1 CCDC173 CCDC173 C9orf116 C9orf116 EFHC2 EFHC2 ETV1 ETV1 PAQR8 PAQR8 IQUB IQUB CFAP299 CFAP299 C15orf65 C15orf65 RIBC2 RIBC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIB2Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. (343 aa)
TEKT2Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. (430 aa)
CCDC113Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation. (377 aa)
FAM149B1Protein FAM149B1; Family with sequence similarity 149 member B1. (582 aa)
C11orf1UPF0686 protein C11orf1; Chromosome 11 open reading frame 1. (150 aa)
MNS1Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family. (495 aa)
EFCAB1EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. (211 aa)
CFAP20Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation. (193 aa)
EFCAB6EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. (1501 aa)
TEKT5Tektin-5; May be a structural component of the sperm flagellum. (485 aa)
CFAP161Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. (301 aa)
TEKT4Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family. (435 aa)
ARMC3Armadillo repeat containing 3. (872 aa)
CCDC96Coiled-coil domain containing 96. (555 aa)
TRIB1Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1- binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts wit [...] (372 aa)
C19orf71Uncharacterized protein C19orf71; Chromosome 19 open reading frame 71. (209 aa)
ENKUREnkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. (256 aa)
SPAG16Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity). (631 aa)
FAM166CProtein FAM166C; Family with sequence similarity 166 member C; Belongs to the FAM166C family. (201 aa)
FAM183AProtein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family. (134 aa)
PACRGParkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. (296 aa)
CFAP52Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. (620 aa)
SPAG8Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. (501 aa)
TEKT1Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family. (418 aa)
CFAP77Cilia and flagella associated protein 77. (320 aa)
CFAP126Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. (177 aa)
CFAP45Cilia and flagella associated protein 45. (551 aa)
C1orf189Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. (101 aa)
CFAP206Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes. (622 aa)
C1orf194Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis. (157 aa)
EFHC1EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. (640 aa)
SPACA9Sperm acrosome associated 9. (222 aa)
DNAJC9DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. (260 aa)
STK40Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. (440 aa)
SPAG6Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. (509 aa)
C9orf135Protein C9orf135; Chromosome 9 open reading frame 135. (229 aa)
C4orf47UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family. (309 aa)
TEKT3Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. (490 aa)
TBC1D32Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). (1257 aa)
CFAP53Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)
FAM166BProtein FAM166B; Family with sequence similarity 166 member B; Belongs to the UPF0605 family. (275 aa)
C5orf49Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. (147 aa)
MEIG1Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis. (88 aa)
CCDC173Coiled-coil domain containing 173. (552 aa)
C9orf116UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. (136 aa)
EFHC2EF-hand domain-containing family member C2; EF-hand domain containing 2. (749 aa)
ETV1ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; Belongs to the ETS family. (477 aa)
PAQR8Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. Belongs to the ADIPOR family. (354 aa)
IQUBIQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance. (791 aa)
CFAP299Cilia- and flagella-associated protein 299; May be involved in spermatogenesis. (250 aa)
C15orf65Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65. (121 aa)
RIBC2RIB43A domain with coiled-coils 2. (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.