STRINGSTRING
TEKT2 TEKT2 MNS1 MNS1 CFAP161 CFAP161 TEKT4 TEKT4 ENKUR ENKUR FAM183A FAM183A CFAP52 CFAP52 SPAG8 SPAG8 TEKT1 TEKT1 CFAP77 CFAP77 CFAP126 CFAP126 CFAP45 CFAP45 C1orf194 C1orf194 SPACA9 SPACA9 C9orf135 C9orf135 TEKT3 TEKT3 CFAP53 CFAP53 FAM166B FAM166B C5orf49 C5orf49 CCDC173 CCDC173 C9orf116 C9orf116 EFHC2 EFHC2 C15orf65 C15orf65
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEKT2Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. (430 aa)
MNS1Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family. (495 aa)
CFAP161Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. (301 aa)
TEKT4Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family. (435 aa)
ENKUREnkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. (256 aa)
FAM183AProtein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family. (134 aa)
CFAP52Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. (620 aa)
SPAG8Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. (501 aa)
TEKT1Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family. (418 aa)
CFAP77Cilia and flagella associated protein 77. (320 aa)
CFAP126Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. (177 aa)
CFAP45Cilia and flagella associated protein 45. (551 aa)
C1orf194Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis. (157 aa)
SPACA9Sperm acrosome associated 9. (222 aa)
C9orf135Protein C9orf135; Chromosome 9 open reading frame 135. (229 aa)
TEKT3Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. (490 aa)
CFAP53Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)
FAM166BProtein FAM166B; Family with sequence similarity 166 member B; Belongs to the UPF0605 family. (275 aa)
C5orf49Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. (147 aa)
CCDC173Coiled-coil domain containing 173. (552 aa)
C9orf116UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. (136 aa)
EFHC2EF-hand domain-containing family member C2; EF-hand domain containing 2. (749 aa)
C15orf65Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65. (121 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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