17 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TEKT2	Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. (430 aa)
	CFAP161	Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. (301 aa)
	TEKT4	Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family. (435 aa)
	ENKUR	Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. (256 aa)
	FAM183A	Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family. (134 aa)
	CFAP52	Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. (620 aa)
	SPAG8	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. (501 aa)
	TEKT1	Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family. (418 aa)
	CFAP126	Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. (177 aa)
	CFAP45	Cilia and flagella associated protein 45. (551 aa)
	C1orf194	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis. (157 aa)
	TEKT3	Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. (490 aa)
	CFAP53	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)
	C5orf49	Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. (147 aa)
	C9orf116	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. (136 aa)
	EFHC2	EF-hand domain-containing family member C2; EF-hand domain containing 2. (749 aa)
	C15orf65	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65. (121 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf65	C1orf194	ENSP00000456337	ENSP00000358965	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	0.828
C15orf65	C5orf49	ENSP00000456337	ENSP00000382708	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.	0.826
C15orf65	C9orf116	ENSP00000456337	ENSP00000395281	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	0.886
C15orf65	CFAP126	ENSP00000456337	ENSP00000356951	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.	0.831
C15orf65	CFAP161	ENSP00000456337	ENSP00000286732	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.	0.863
C15orf65	CFAP45	ENSP00000456337	ENSP00000357079	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Cilia and flagella associated protein 45.	0.819
C15orf65	CFAP52	ENSP00000456337	ENSP00000339449	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.	0.814
C15orf65	CFAP53	ENSP00000456337	ENSP00000381553	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	0.895
C15orf65	EFHC2	ENSP00000456337	ENSP00000404232	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.871
C15orf65	ENKUR	ENSP00000456337	ENSP00000331044	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.	0.802
C15orf65	FAM183A	ENSP00000456337	ENSP00000334415	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family.	0.802
C15orf65	SPAG8	ENSP00000456337	ENSP00000340982	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.824
C15orf65	TEKT1	ENSP00000456337	ENSP00000341346	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family.	0.840
C15orf65	TEKT2	ENSP00000456337	ENSP00000207457	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.	0.826
C15orf65	TEKT3	ENSP00000456337	ENSP00000379263	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility.	0.862
C15orf65	TEKT4	ENSP00000456337	ENSP00000295201	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family.	0.834
C1orf194	C15orf65	ENSP00000358965	ENSP00000456337	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.	0.828
C1orf194	C5orf49	ENSP00000358965	ENSP00000382708	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.	0.875
C1orf194	C9orf116	ENSP00000358965	ENSP00000395281	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	0.849
C1orf194	CFAP126	ENSP00000358965	ENSP00000356951	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.	0.931