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GNPTG GNPTG ZNF385D ZNF385D FSTL1 FSTL1 GNPTAB GNPTAB NAGPA NAGPA CCDC63 CCDC63 KIAA0319L KIAA0319L DNAAF4 DNAAF4 OR4F6 OR4F6 CCDC87 CCDC87 HECTD4 HECTD4 KIAA0319 KIAA0319 DCDC2 DCDC2 ZNF860 ZNF860 HERPUD2 HERPUD2 DCDC2C DCDC2C DCDC2B DCDC2B ACAD10 ACAD10 DIP2A DIP2A ATP2C2 ATP2C2 NFXL1 NFXL1 CMIP CMIP
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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GNPTGN-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. (305 aa)
ZNF385DZinc finger protein 385D. (395 aa)
FSTL1Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). (308 aa)
GNPTABN-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. (1256 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. (515 aa)
CCDC63Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. (563 aa)
KIAA0319LDyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R. (1049 aa)
DNAAF4Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. (420 aa)
OR4F6Olfactory receptor 4F6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)
CCDC87Coiled-coil domain-containing protein 87; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility; Belongs to the CCDC87 family. (849 aa)
HECTD4Probable E3 ubiquitin-protein ligase HECTD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (4416 aa)
KIAA0319Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. (1072 aa)
DCDC2Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length. (476 aa)
ZNF860Zinc finger protein 860; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (632 aa)
HERPUD2Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway. (406 aa)
DCDC2CDoublecortin domain containing 2C. (364 aa)
DCDC2BDoublecortin domain containing 2B. (349 aa)
ACAD10Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2-methyl- C15-CoA. (1090 aa)
DIP2ADisco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. (1571 aa)
ATP2C2Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (975 aa)
NFXL1NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1. (911 aa)
CMIPC-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. (773 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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