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| | ZPBP | Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity). (351 aa) |
| | FNDC8 | Fibronectin type III domain containing 8. (324 aa) |
| | ROPN1 | Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. (212 aa) |
| | ACR | Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (421 aa) |
| | TULP2 | TUB like protein 2; Belongs to the TUB family. (520 aa) |
| | AKAP3 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. (853 aa) |
| | ZBTB47 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation. (747 aa) |
| | TNP1 | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family. (55 aa) |
| | SPACA1 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility. (294 aa) |
| | PMFBP1 | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton (By similarity). (1007 aa) |
| | SOX4 | Transcription factor SOX-4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. (474 aa) |
| | TSKS | Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development. (592 aa) |
| | PKDREJ | Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family. (2253 aa) |
| | C3orf20 | Uncharacterized protein C3orf20; Chromosome 3 open reading frame 20. (904 aa) |
| | PEBP4 | Phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization. Belongs to the phosphatidylethanolamine-binding protein family. (227 aa) |
| | FAM186B | Protein FAM186B; Family with sequence similarity 186 member B. (893 aa) |
| | CCDC54 | Coiled-coil domain containing 54. (328 aa) |
| | CRISPLD2 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family. (497 aa) |
| | ANKRD7 | Ankyrin repeat domain 7. (254 aa) |
| | CREM | cAMP-responsive element modulator; Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. (300 aa) |
| | ADAM2 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. (735 aa) |
| | FSCN3 | Fascin-3; Acts as an actin bundling protein; Belongs to the fascin family. (498 aa) |
| | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (608 aa) |
| | GLIPR1 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. (266 aa) |
| | ADAD2 | Adenosine deaminase domain containing 2. (665 aa) |
| | SPACA3 | Sperm acrosome membrane-associated protein 3, processed form; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. (215 aa) |
| | CALR3 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. (384 aa) |
| | TRIM7 | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation. Belongs to the TRIM/RBCC family. (511 aa) |
| | KIAA1755 | Uncharacterized protein KIAA1755; KIAA1755. (1200 aa) |
| | CCDC83 | Coiled-coil domain containing 83. (444 aa) |
| | SPACA7 | Sperm acrosome-associated protein 7; Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion. (195 aa) |
| | ODF1 | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. (250 aa) |
| | ARMC12 | Armadillo repeat containing 12. (367 aa) |
| | C9orf43 | Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43. (461 aa) |
| | CIB4 | Calcium and integrin binding family member 4. (185 aa) |
| | RHPN1 | Rhophilin-1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules; Belongs to the RHPN family. (670 aa) |
| | M1AP | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. (530 aa) |
| | SPATC1L | Speriolin-like protein; Spermatogenesis and centriole associated 1 like. (340 aa) |
| | TMEM190 | Transmembrane protein 190. (177 aa) |
| | KLHL10 | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. (608 aa) |
| | IZUMO2 | Izumo sperm-egg fusion protein 2; IZUMO family member 2. (221 aa) |
| | CCDC42 | Coiled-coil domain-containing protein 42; Required for sperm development. (316 aa) |
| | FAM71A | Protein FAM71A; Family with sequence similarity 71 member A; Belongs to the FAM71 family. (594 aa) |
| | DCST1 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. (706 aa) |
| | PRSS37 | Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system ; Belongs to the peptidase S1 family. (235 aa) |
| | SSMEM1 | Serine rich single-pass membrane protein 1. (244 aa) |
| | C12orf50 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. (414 aa) |
| | SPATA19 | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis. (167 aa) |
| | CCDC182 | Coiled-coil domain containing 182. (153 aa) |
| | PCSK4 | Proprotein convertase subtilisin/kexin type 4; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be throu [...] (755 aa) |
| | TMEM37 | Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). (190 aa) |
| | PDILT | Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis; Belongs to the protein disulfide isomerase family. (584 aa) |
| | FAM71B | Protein FAM71B; May be involved in RNA biogenesis. (605 aa) |
| | SPACA5 | Sperm acrosome associated 5. (159 aa) |
| | IQCF1 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. (205 aa) |
| | C9orf131 | Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131. (1079 aa) |
| | FAM170B | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. (283 aa) |
| | PRM1 | Sperm protamine P1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. (51 aa) |
| | SPESP1 | Sperm equatorial segment protein 1; Involved in fertilization ability of sperm. Belongs to the SPESP1 family. (350 aa) |
| | SPACA4 | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. (124 aa) |
| | EDDM3A | Epididymal secretory protein E3-alpha; Possible function in sperm maturation. (147 aa) |
| | SPEM1 | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. (309 aa) |
| | DPY19L2 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation; Belongs to the dpy-19 family. (758 aa) |
| | TMEM270 | Transmembrane protein 270. (265 aa) |
| | TPPP2 | Tubulin polymerization-promoting protein family member 2; Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity. (170 aa) |
| | C12orf40 | Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40. (652 aa) |
| | CCDC89 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. (374 aa) |
| | C16orf89 | UPF0764 protein C16orf89; Chromosome 16 open reading frame 89; Belongs to the UPF0764 family. (402 aa) |
| | CDPF1 | Cysteine rich DPF motif domain containing 1. (123 aa) |
| | C11orf71 | Uncharacterized protein C11orf71; Chromosome 11 open reading frame 71. (147 aa) |
| | PRM3 | Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity). (103 aa) |
| | TNP2 | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (138 aa) |
| | ODF3 | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. (254 aa) |
| | FHL5 | Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner. (284 aa) |
| | FAM71F1 | Protein FAM71F1; Family with sequence similarity 71 member F1. (344 aa) |
| | TMCO5A | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family. (288 aa) |
| | IZUMO1 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. (350 aa) |
| | TMEM121B | Transmembrane protein 121B. (578 aa) |
| | TMEM89 | Transmembrane protein 89. (159 aa) |
| | OR2T34 | Olfactory receptor 2T34; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | ODF4 | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. (257 aa) |
| | IZUMO1R | Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. (250 aa) |
| | WBP2NL | Postacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. (309 aa) |
| | PRSS55 | Serine protease 55; Probable serine protease. (352 aa) |
| | RNASE10 | Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity). (216 aa) |
| | CFAP73 | Cilia- and flagella-associated protein 73; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Belongs to the CFAP73 family. (308 aa) |
| | GGN | Gametogenetin; May be involved in spermatogenesis. (652 aa) |
| | CRISP1 | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family. (249 aa) |
| | TSSK4 | Testis-specific serine/threonine-protein kinase 4; Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (338 aa) |
| | ZFAND4 | Zinc finger AN1-type containing 4. (727 aa) |
| | SLC35E4 | Solute carrier family 35 member E4; Putative transporter. (350 aa) |
| | TMEM202 | Transmembrane protein 202. (273 aa) |
| | SPATA16 | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. (569 aa) |
| | CCDC38 | Coiled-coil domain containing 38. (563 aa) |
| | MORN3 | MORN repeat containing 3. (240 aa) |
| | UBQLN3 | Ubiquilin-3; Ubiquilin 3. (655 aa) |
| | SUN5 | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. (379 aa) |
| | C12orf29 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. (325 aa) |
| | CCER1 | Coiled-coil glutamate rich protein 1. (406 aa) |
| | LRRCC1 | Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. (1032 aa) |
| | DDIT4L | DNA damage-inducible transcript 4-like protein; Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. (193 aa) |
| | SHCBP1L | Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells. (653 aa) |
| | SPATA46 | Spermatogenesis-associated protein 46; Plays a role in spermiogenesis and fertilization. (261 aa) |
| | TSACC | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. (125 aa) |
| | DCST2 | DC-STAMP domain containing 2. (773 aa) |
| | SMCP | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). (116 aa) |
| | C1orf56 | Protein MENT; Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B. (341 aa) |
| | RWDD2A | RWD domain containing 2A. (292 aa) |
| | FAM209A | Protein FAM209A; Family with sequence similarity 209 member A. (171 aa) |
| | SPATA6 | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits; Belongs to the SPATA6 family. (488 aa) |
| | CT83 | Kita-kyushu lung cancer antigen 1; Cancer/testis antigen 83. (113 aa) |
| | EFCAB14 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14. (495 aa) |
| | TMCO2 | Transmembrane and coiled-coil domains 2. (182 aa) |
| | GTSF1L | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like. (148 aa) |
| | TSSK3 | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (268 aa) |
| | MORN5 | MORN repeat containing 5. (161 aa) |
| | CXorf65 | Uncharacterized protein CXorf65; Chromosome X open reading frame 65. (183 aa) |
| | SPAG4 | Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODF [...] (437 aa) |
| | TMEM225 | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. (225 aa) |
| | LYZL2 | Lysozyme-like protein 2; Lysozyme like 2. (194 aa) |
| | C9orf64 | Queuosine salvage protein; Involved in salvaging queuosine. (341 aa) |
| | GKAP1 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. (366 aa) |
| | SCP2D1 | SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1. (156 aa) |
| | SPATC1 | Speriolin; Spermatogenesis and centriole associated 1; Belongs to the speriolin family. (591 aa) |
| | GLIPR2 | Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2. (154 aa) |
| | FBXO47 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. (452 aa) |
| | ACTRT2 | Actin related protein T2. (377 aa) |
| | GLIPR1L1 | GLIPR1-like protein 1; Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9- positive microvesicules found in the cauda region. (242 aa) |
| | CCDC3 | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity). (270 aa) |
| | ADAM32 | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. (787 aa) |
| | TMEM95 | Transmembrane protein 95. (203 aa) |
| | CEP112 | Centrosomal protein 112. (955 aa) |
| | TSGA10 | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. (698 aa) |
| | IZUMO4 | Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family. (232 aa) |
| | INS-IGF2 | Insulin, isoform 2; INS-IGF2 readthrough. (200 aa) |
| | CAPN11 | Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (739 aa) |
| | RADIL | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Belongs to the RADIL family. (1075 aa) |
| | TSSK2 | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. (358 aa) |
| | MAGEB16 | Melanoma-associated antigen B16; MAGE family member B16. (324 aa) |
| | OAZ3 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER- Golgi intermediate compartment (ERGIC) to the cytos [...] (235 aa) |
| | C22orf23 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. (217 aa) |
| | TEX33 | Testis-expressed protein 33; Testis expressed 33. (280 aa) |
| | OR2A2 | Olfactory receptor 2A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | LLCFC1 | LLLL and CFNLAS motif containing 1. (147 aa) |
| | SPATA3 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. (192 aa) |
| | RIMBP3C | RIMS-binding protein 3C; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. (1639 aa) |
| | CLGN | Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). (610 aa) |
| | IQCF5 | IQ motif containing F5. (148 aa) |
| | C11orf94 | Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94. (98 aa) |
| | C20orf173 | Uncharacterized protein C20orf173; Chromosome 20 open reading frame 173. (202 aa) |
| | PRM2 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. (140 aa) |
| | C2CD6 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. (1820 aa) |
| | FAM221B | Protein FAM221B; Family with sequence similarity 221 member B. (402 aa) |
| | FAM205A | Protein FAM205A; Family with sequence similarity 205 member A. (1335 aa) |
| | ZNF782 | Zinc finger protein 782; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (699 aa) |
| | EFCAB12 | EF-hand calcium-binding domain-containing protein 12; EF-hand calcium binding domain 12. (572 aa) |
| | ROPN1L | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. (230 aa) |
| | RANBP3L | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. (490 aa) |
| | SPINK2 | Serine peptidase inhibitor Kazal type 2. (134 aa) |
| | ROPN1B | Ropporin-1B; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. (212 aa) |
| | HMGB4 | High mobility group box 4; Belongs to the HMGB family. (186 aa) |
| | SPA17 | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). (151 aa) |
| | RITA1 | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. (293 aa) |
| | TEX38 | Testis-expressed protein 38; Testis expressed 38. (206 aa) |
| | CCDC187 | Coiled-coil domain containing 187. (965 aa) |
| | TSSK6 | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). (273 aa) |
| | IZUMO3 | Izumo sperm-egg fusion protein 3; IZUMO family member 3. (233 aa) |
| | CDC42SE1 | CDC42 small effector protein 1; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages; Belongs to the CDC42SE/SPEC family. (79 aa) |
| | GGNBP2 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. (697 aa) |
| | RIMBP3B | RIMS-binding protein 3B; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. (1639 aa) |
| | ZAN | Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. (2812 aa) |
| | FAM71D | Protein FAM71D; Family with sequence similarity 71 member D. (422 aa) |
| | RIMBP3 | RIMS-binding protein 3A; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development; Belongs to the RIMBP family. (1639 aa) |
| | CABYR | Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. (493 aa) |
| | CRISP2 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. (243 aa) |
| | MEIKIN | Meiosis-specific kinetochore protein; Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin- dependent protection [...] (373 aa) |
| | SPACA6 | Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion. (324 aa) |
| | PMIS2 | Transmembrane protein PMIS2; May play a role in spermatozoa mobility. Belongs to the CD225/Dispanin family. (150 aa) |
| | SPATS1 | Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1. (300 aa) |
