STRINGSTRING
TSKS TSKS CIB4 CIB4 FAM170B FAM170B TSSK4 TSSK4 TSSK2 TSSK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TSKSTestis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development. (592 aa)
CIB4Calcium and integrin binding family member 4. (185 aa)
FAM170BProtein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. (283 aa)
TSSK4Testis-specific serine/threonine-protein kinase 4; Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (338 aa)
TSSK2Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. (358 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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