STRINGSTRING
TSPAN32 TSPAN32 MEST MEST ZNF331 ZNF331 USP29 USP29 ZIM3 ZIM3 PHLDA2 PHLDA2 NAP1L5 NAP1L5 PEG3 PEG3 DLK1 DLK1 PLAGL1 PLAGL1 DIRAS3 DIRAS3 FAM50B FAM50B SLC22A18 SLC22A18 HERC3 HERC3 ZNF716 ZNF716 BLCAP BLCAP C11orf21 C11orf21 PEG10 PEG10 DIO3 DIO3 ZIM2 ZIM2 SLC22A18AS SLC22A18AS SGCE SGCE MCTS2P MCTS2P NNAT NNAT ZDBF2 ZDBF2 RTL1 RTL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSPAN32Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (320 aa)
MESTMesoderm-specific transcript homolog protein; Mesoderm specific transcript; Belongs to the AB hydrolase superfamily. (335 aa)
ZNF331Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis. (463 aa)
USP29Ubiquitin specific peptidase 29. (922 aa)
ZIM3Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (472 aa)
PHLDA2Pleckstrin homology-like domain family A member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). Belongs to the PHLDA2 family. (152 aa)
NAP1L5Nucleosome assembly protein 1 like 5. (182 aa)
PEG3Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family. (1588 aa)
DLK1Protein delta homolog 1; May have a role in neuroendocrine differentiation. (383 aa)
PLAGL1Zinc finger protein PLAGL1; Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. (463 aa)
DIRAS3GTP-binding protein Di-Ras3; DIRAS family GTPase 3. (229 aa)
FAM50BProtein FAM50B; Family with sequence similarity 50 member B. (325 aa)
SLC22A18Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (424 aa)
HERC3Probable E3 ubiquitin-protein ligase HERC3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (1050 aa)
ZNF716Zinc finger protein 716; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (495 aa)
BLCAPBladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. (87 aa)
C11orf21Uncharacterized protein C11orf21; Chromosome 11 open reading frame 21. (178 aa)
PEG10Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] (401 aa)
DIO3Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. (304 aa)
ZIM2Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (527 aa)
SLC22A18ASBeckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein; Solute carrier family 22 member 18 antisense. (150 aa)
SGCEEpsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. (473 aa)
MCTS2PMalignant T-cell-amplified sequence; MCTS family member 2, pseudogene. (181 aa)
NNATNeuronatin; May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels. (81 aa)
ZDBF2DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2. (2354 aa)
RTL1Retrotransposon-like protein 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. (1358 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (36%) [HD]