STRINGSTRING
PI15 PI15 SCUBE3 SCUBE3 FAM180A FAM180A SLC25A29 SLC25A29 ANKS1A ANKS1A SCUBE1 SCUBE1 ZNF76 ZNF76 C4orf48 C4orf48 BEGAIN BEGAIN ENSP00000418875 ENSP00000418875 LRRC75A LRRC75A KLHL35 KLHL35 THEGL THEGL TCP11 TCP11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PI15Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. (258 aa)
SCUBE3Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. (993 aa)
FAM180AProtein FAM180A; Family with sequence similarity 180 member A. (173 aa)
SLC25A29Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms ; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
ANKS1AAnkyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). (1134 aa)
SCUBE1Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. (988 aa)
ZNF76Zinc finger protein 76; May be involved in transcriptional regulation. (570 aa)
C4orf48Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48. (128 aa)
BEGAINBrain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD). (593 aa)
ENSP00000418875Probable threonine protease PRSS50. (385 aa)
LRRC75ALeucine-rich repeat-containing protein 75A; Leucine rich repeat containing 75A. (344 aa)
KLHL35Kelch-like protein 35; Kelch like family member 35. (583 aa)
THEGLTesticular haploid expressed gene protein-like; Theg spermatid protein like. (465 aa)
TCP11T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization- promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Belongs to the TCP11 family. (516 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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