STRINGSTRING
ATAD2B ATAD2B ARHGAP20 ARHGAP20 RPS6KA6 RPS6KA6 PHIP PHIP CPXCR1 CPXCR1 CYLC1 CYLC1 CCIN CCIN OPHN1 OPHN1 ZNF711 ZNF711 TENT5C TENT5C IL1RAPL2 IL1RAPL2 KLHL4 KLHL4 DACH2 DACH2 POF1B POF1B BRWD3 BRWD3 SP140 SP140 SP140L SP140L CYLC2 CYLC2 SATL1 SATL1 CSNKA2IP CSNKA2IP POU3F4 POU3F4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATAD2BATPase family AAA domain containing 2B. (1458 aa)
ARHGAP20Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (1191 aa)
RPS6KA6Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. (745 aa)
PHIPPH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. (1821 aa)
CPXCR1CPX chromosome region candidate 1. (301 aa)
CYLC1Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. (651 aa)
CCINCalicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. (588 aa)
OPHN1Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). (802 aa)
ZNF711Zinc finger protein 711; Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C. Belongs to the krueppel C2H2-type zinc-finger protein family. (807 aa)
TENT5CTerminal nucleotidyltransferase 5C; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. (391 aa)
IL1RAPL2Interleukin 1 receptor accessory protein like 2; Belongs to the interleukin-1 receptor family. (686 aa)
KLHL4Kelch-like protein 4; Kelch like family member 4. (720 aa)
DACH2Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlyin [...] (599 aa)
POF1BProtein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. (595 aa)
BRWD3Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. (1802 aa)
SP140Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. (867 aa)
SP140LSP140 nuclear body protein like. (580 aa)
CYLC2Cylicin-2; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. (348 aa)
SATL1Spermidine/spermine N1-acetyl transferase like 1. (632 aa)
CSNKA2IPCasein kinase II subunit alpha'-interacting protein; May play a role in chromatin regulation of male germ cells. (734 aa)
POU3F4POU domain, class 3, transcription factor 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. (361 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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