(13 nodes) Mixed, incl. Methyltransferase domain, and ubiE/COQ5 methyltransferase family network (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	METTL25	Methyltransferase-like protein 25; Putative methyltransferase. (603 aa)
	METTL2B	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family. (378 aa)
	IGSF6	Immunoglobulin superfamily member 6. (241 aa)
	METTL27	Methyltransferase-like protein 27; Methyltransferase like 27. (245 aa)
	METTL2A	tRNA N(3)-methylcytidine methyltransferase METTL2A; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family. (378 aa)
	METTL24	Methyltransferase-like protein 24; Methyltransferase like 24. (366 aa)
	DALRD3	DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3. (543 aa)
	METTL9	Methyltransferase-like protein 9; Methyltransferase like 9. (318 aa)
	RRNAD1	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family. (475 aa)
	METTL7B	Methyltransferase-like protein 7B; Probable methyltransferase. (244 aa)
	IQCD	Dynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the DRC10 family. (449 aa)
	METTL11B	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. (283 aa)
	METTL26	Methyltransferase like 26. (205 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DALRD3	METTL2A	ENSP00000344989	ENSP00000309610	DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3.	tRNA N(3)-methylcytidine methyltransferase METTL2A; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.605
DALRD3	METTL2B	ENSP00000344989	ENSP00000262432	DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3.	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.599
IGSF6	METTL9	ENSP00000268389	ENSP00000350874	Immunoglobulin superfamily member 6.	Methyltransferase-like protein 9; Methyltransferase like 9.	0.972
IQCD	METTL27	ENSP00000400669	ENSP00000297873	Dynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the DRC10 family.	Methyltransferase-like protein 27; Methyltransferase like 27.	0.606
METTL11B	METTL25	ENSP00000408058	ENSP00000248306	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase-like protein 25; Putative methyltransferase.	0.474
METTL11B	METTL26	ENSP00000408058	ENSP00000440765	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase like 26.	0.477
METTL11B	METTL27	ENSP00000408058	ENSP00000297873	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase-like protein 27; Methyltransferase like 27.	0.579
METTL11B	METTL7B	ENSP00000408058	ENSP00000377796	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase-like protein 7B; Probable methyltransferase.	0.448
METTL11B	METTL9	ENSP00000408058	ENSP00000350874	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase-like protein 9; Methyltransferase like 9.	0.449
METTL11B	RRNAD1	ENSP00000408058	ENSP00000357199	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family.	0.484
METTL24	METTL25	ENSP00000344071	ENSP00000248306	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase-like protein 25; Putative methyltransferase.	0.556
METTL24	METTL26	ENSP00000344071	ENSP00000440765	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase like 26.	0.410
METTL24	METTL2B	ENSP00000344071	ENSP00000262432	Methyltransferase-like protein 24; Methyltransferase like 24.	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.653
METTL24	METTL7B	ENSP00000344071	ENSP00000377796	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase-like protein 7B; Probable methyltransferase.	0.413
METTL24	METTL9	ENSP00000344071	ENSP00000350874	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase-like protein 9; Methyltransferase like 9.	0.572
METTL25	METTL11B	ENSP00000248306	ENSP00000408058	Methyltransferase-like protein 25; Putative methyltransferase.	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	0.474
METTL25	METTL24	ENSP00000248306	ENSP00000344071	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 24; Methyltransferase like 24.	0.556
METTL25	METTL26	ENSP00000248306	ENSP00000440765	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase like 26.	0.553
METTL25	METTL27	ENSP00000248306	ENSP00000297873	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 27; Methyltransferase like 27.	0.537
METTL25	METTL2A	ENSP00000248306	ENSP00000309610	Methyltransferase-like protein 25; Putative methyltransferase.	tRNA N(3)-methylcytidine methyltransferase METTL2A; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.528