(7 nodes) Methyltransferase domain, and ubiE/COQ5 methyltransferase family network (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	METTL25	Methyltransferase-like protein 25; Putative methyltransferase. (603 aa)
	METTL2B	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family. (378 aa)
	METTL24	Methyltransferase-like protein 24; Methyltransferase like 24. (366 aa)
	RRNAD1	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family. (475 aa)
	METTL7B	Methyltransferase-like protein 7B; Probable methyltransferase. (244 aa)
	METTL11B	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. (283 aa)
	METTL26	Methyltransferase like 26. (205 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
METTL11B	METTL25	ENSP00000408058	ENSP00000248306	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase-like protein 25; Putative methyltransferase.	0.474
METTL11B	METTL26	ENSP00000408058	ENSP00000440765	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase like 26.	0.477
METTL11B	METTL7B	ENSP00000408058	ENSP00000377796	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Methyltransferase-like protein 7B; Probable methyltransferase.	0.448
METTL11B	RRNAD1	ENSP00000408058	ENSP00000357199	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family.	0.484
METTL24	METTL25	ENSP00000344071	ENSP00000248306	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase-like protein 25; Putative methyltransferase.	0.556
METTL24	METTL26	ENSP00000344071	ENSP00000440765	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase like 26.	0.410
METTL24	METTL2B	ENSP00000344071	ENSP00000262432	Methyltransferase-like protein 24; Methyltransferase like 24.	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.653
METTL24	METTL7B	ENSP00000344071	ENSP00000377796	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase-like protein 7B; Probable methyltransferase.	0.413
METTL25	METTL11B	ENSP00000248306	ENSP00000408058	Methyltransferase-like protein 25; Putative methyltransferase.	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	0.474
METTL25	METTL24	ENSP00000248306	ENSP00000344071	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 24; Methyltransferase like 24.	0.556
METTL25	METTL26	ENSP00000248306	ENSP00000440765	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase like 26.	0.553
METTL25	METTL2B	ENSP00000248306	ENSP00000262432	Methyltransferase-like protein 25; Putative methyltransferase.	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.756
METTL25	METTL7B	ENSP00000248306	ENSP00000377796	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 7B; Probable methyltransferase.	0.748
METTL26	METTL11B	ENSP00000440765	ENSP00000408058	Methyltransferase like 26.	Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	0.477
METTL26	METTL24	ENSP00000440765	ENSP00000344071	Methyltransferase like 26.	Methyltransferase-like protein 24; Methyltransferase like 24.	0.410
METTL26	METTL25	ENSP00000440765	ENSP00000248306	Methyltransferase like 26.	Methyltransferase-like protein 25; Putative methyltransferase.	0.553
METTL26	METTL2B	ENSP00000440765	ENSP00000262432	Methyltransferase like 26.	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.432
METTL26	METTL7B	ENSP00000440765	ENSP00000377796	Methyltransferase like 26.	Methyltransferase-like protein 7B; Probable methyltransferase.	0.410
METTL26	RRNAD1	ENSP00000440765	ENSP00000357199	Methyltransferase like 26.	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family.	0.476
METTL2B	METTL24	ENSP00000262432	ENSP00000344071	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	Methyltransferase-like protein 24; Methyltransferase like 24.	0.653