STRINGSTRING
PLEKHG3 PLEKHG3 CDC42EP1 CDC42EP1 CZIB CZIB LRATD1 LRATD1 KIAA0355 KIAA0355 DERPC DERPC RESF1 RESF1 MAP3K15 MAP3K15 ARHGEF10L ARHGEF10L NHS NHS NRK NRK RAI2 RAI2 ARMCX5 ARMCX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLEKHG3Pleckstrin homology and RhoGEF domain containing G3. (1219 aa)
CDC42EP1Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. (391 aa)
CZIBCXXC motif containing zinc binding protein; Belongs to the UPF0587 family. (160 aa)
LRATD1Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. (292 aa)
KIAA0355Uncharacterized protein KIAA0355. (1070 aa)
DERPCDecreased expression in renal and prostate cancer protein; Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed; Belongs to the DERPC family. (524 aa)
RESF1Retroelement silencing factor 1; Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. (1747 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. (1313 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. (1279 aa)
NHSNance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development; Belongs to the NHS family. (1630 aa)
NRKNik-related protein kinase; May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1582 aa)
RAI2Retinoic acid induced 2. (530 aa)
ARMCX5Armadillo repeat containing X-linked 5. (558 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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