STRINGSTRING
SLC6A7 SLC6A7 IGSF21 IGSF21 LTK LTK BARX2 BARX2 PRAC1 PRAC1 HOXB13 HOXB13 NR2F6 NR2F6 SSX7 SSX7 PHOX2A PHOX2A SUSD5 SUSD5 ARHGAP32 ARHGAP32 ZNF540 ZNF540 RESP18 RESP18 NRIP2 NRIP2 OR14I1 OR14I1 ALKAL1 ALKAL1 IGSF9 IGSF9 TCERG1L TCERG1L FAM78A FAM78A PABPC1L2B PABPC1L2B LRRC38 LRRC38 C1orf127 C1orf127 FABP9 FABP9 C17orf107 C17orf107 KLHDC7A KLHDC7A TAFA5 TAFA5 ALKAL2 ALKAL2 MPPED1 MPPED1 TMEM132D TMEM132D TMEM132C TMEM132C IGSF22 IGSF22 HELT HELT INSYN2A INSYN2A IQSEC3 IQSEC3 RIMS4 RIMS4 LRTM2 LRTM2 INSYN1 INSYN1 PRAC2 PRAC2 TEX52 TEX52 LOC101059915 LOC101059915 OR4K14 OR4K14 OR5A1 OR5A1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SLC6A7Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals. (636 aa)
IGSF21Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. (467 aa)
LTKLeukocyte tyrosine kinase receptor; Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. (864 aa)
BARX2Homeobox protein BarH-like 2; Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). (279 aa)
PRAC1PRAC1 small nuclear protein. (57 aa)
HOXB13Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Belongs to the Abd-B homeobox family. (284 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcripti [...] (404 aa)
SSX7Protein SSX7; Could act as a modulator of transcription; Belongs to the SSX family. (188 aa)
PHOX2APaired mesoderm homeobox protein 2A; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. (284 aa)
SUSD5Sushi domain containing 5. (629 aa)
ARHGAP32Rho GTPase-activating protein 32; GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). Belongs to the PX domain-containing GAP family. (2087 aa)
ZNF540Zinc finger protein 540; May act as a transcriptional repressor. (660 aa)
RESP18Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. (228 aa)
NRIP2Nuclear receptor-interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2. (281 aa)
OR14I1Olfactory receptor 14I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (311 aa)
ALKAL1ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. (129 aa)
IGSF9Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation. Belongs to the immunoglobulin superfamily. Turtle family. (1179 aa)
TCERG1LTranscription elongation regulator 1 like. (586 aa)
FAM78AProtein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. (283 aa)
PABPC1L2Bpoly(A) binding protein cytoplasmic 1 like 2B. (200 aa)
LRRC38Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. (294 aa)
C1orf127Uncharacterized protein C1orf127; Chromosome 1 open reading frame 127. (823 aa)
FABP9Fatty acid binding protein 9. (132 aa)
C17orf107Uncharacterized protein C17orf107; Chromosome 17 open reading frame 107. (190 aa)
KLHDC7AKelch domain containing 7A. (777 aa)
TAFA5Chemokine-like protein TAFA-5; Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By simila [...] (132 aa)
ALKAL2ALK and LTK ligand 2; Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation. (152 aa)
MPPED1Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro). (326 aa)
TMEM132DTransmembrane protein 132D; May serve as a cell-surface marker for oligodendrocyte differentiation. (1099 aa)
TMEM132CTransmembrane protein 132C. (1108 aa)
IGSF22Immunoglobulin superfamily member 22. (1326 aa)
HELTHairy and enhancer of split-related protein HELT; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'; Belongs to the HEY family. (242 aa)
INSYN2AInhibitory synaptic factor 2A; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. Belongs to the INSYN2 family. (479 aa)
IQSEC3IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1. (1182 aa)
RIMS4Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. (270 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (370 aa)
INSYN1Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. (293 aa)
PRAC2PRAC2 small nuclear protein. (140 aa)
TEX52Testis-expressed protein 52; Testis expressed 52. (305 aa)
LOC101059915Uncharacterized protein. (518 aa)
OR4K14Olfactory receptor 4K14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa)
OR5A1Olfactory receptor 5A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (315 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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