STRINGSTRING
PRR4 PRR4 STATH STATH PRB4 PRB4 PLGLB1 PLGLB1 PRB2 PRB2 OPRPN OPRPN PRB1 PRB1 HTN1 HTN1 HTN3 HTN3 PRB3 PRB3 SMR3B SMR3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRR4Proline-rich protein 4; Proline rich 4. (134 aa)
STATHStatherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface. (62 aa)
PRB4Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4. (247 aa)
PLGLB1Plasminogen-like protein B; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction. (96 aa)
PRB2Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2. (416 aa)
OPRPNOpiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. Belongs to the PROL1/PROL3 family. (248 aa)
PRB1Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1. (198 aa)
HTN1His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities; Belongs to the histatin/statherin family. (57 aa)
HTN3His3-(20-30)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. (51 aa)
PRB3Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum. (351 aa)
SMR3BSubmaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. (79 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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