STRINGSTRING
DEFB129 DEFB129 DEFB118 DEFB118 DEFB114 DEFB114 DEFB124 DEFB124 DEFB128 DEFB128 DEFB110 DEFB110 DEFB123 DEFB123 DEFB119 DEFB119 DEFB135 DEFB135 DEFB132 DEFB132 DEFB127 DEFB127 DEFB126 DEFB126 DEFB125 DEFB125 DEFB113 DEFB113 DEFB116 DEFB116 DEFB115 DEFB115 DEFB121 DEFB121 DEFB134 DEFB134
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEFB129Beta-defensin 129; Has antibacterial activity. (183 aa)
DEFB118Beta-defensin 118; Has antibacterial activity. (123 aa)
DEFB114Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. (69 aa)
DEFB124Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. (71 aa)
DEFB128Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. (93 aa)
DEFB110Beta-defensin 110; Has antibacterial activity. (67 aa)
DEFB123Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
DEFB119Defensin beta 119. (88 aa)
DEFB135Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family. (77 aa)
DEFB132Beta-defensin 132; Has antibacterial activity; Belongs to the beta-defensin family. (95 aa)
DEFB127Beta-defensin 127; Has antibacterial activity. (99 aa)
DEFB126Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] (111 aa)
DEFB125Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family. (156 aa)
DEFB113Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)
DEFB116Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. (102 aa)
DEFB115Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
DEFB121Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family. (76 aa)
DEFB134Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family. (66 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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