STRINGSTRING
DEFB129 DEFB129 DEFB118 DEFB118 DEFB114 DEFB114 DEFB124 DEFB124 DEFB128 DEFB128 DEFB110 DEFB110 DEFB135 DEFB135 DEFB132 DEFB132 DEFB127 DEFB127 DEFB126 DEFB126 DEFB125 DEFB125 DEFB113 DEFB113 DEFB134 DEFB134
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEFB129Beta-defensin 129; Has antibacterial activity. (183 aa)
DEFB118Beta-defensin 118; Has antibacterial activity. (123 aa)
DEFB114Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. (69 aa)
DEFB124Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. (71 aa)
DEFB128Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. (93 aa)
DEFB110Beta-defensin 110; Has antibacterial activity. (67 aa)
DEFB135Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family. (77 aa)
DEFB132Beta-defensin 132; Has antibacterial activity; Belongs to the beta-defensin family. (95 aa)
DEFB127Beta-defensin 127; Has antibacterial activity. (99 aa)
DEFB126Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] (111 aa)
DEFB125Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family. (156 aa)
DEFB113Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)
DEFB134Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family. (66 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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