STRINGSTRING
PI3 PI3 WFDC3 WFDC3 SPINT4 SPINT4 WFDC13 WFDC13 WFDC9 WFDC9 WFDC10B WFDC10B PRSS35 PRSS35 NEURL2 NEURL2 SPATA25 SPATA25 ZSWIM1 ZSWIM1 WFDC10A WFDC10A WFDC8 WFDC8 EPPIN EPPIN WFDC6 WFDC6 WFDC2 WFDC2 SEMG2 SEMG2 SEMG1 SEMG1 WFDC12 WFDC12 WFDC5 WFDC5 ZSWIM9 ZSWIM9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PI3Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1). (117 aa)
WFDC3WAP four-disulfide core domain 3. (231 aa)
SPINT4Serine peptidase inhibitor, Kunitz type 4. (99 aa)
WFDC13WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor. (93 aa)
WFDC9Protein WFDC9; WAP four-disulfide core domain 9. (89 aa)
WFDC10BProtein WFDC10B; WAP four-disulfide core domain 10B. (89 aa)
PRSS35Serine protease 35; Belongs to the peptidase S1 family. (413 aa)
NEURL2Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). (285 aa)
SPATA25Spermatogenesis-associated protein 25; May play a role in spermatogenesis. Belongs to the SPATA25 family. (227 aa)
ZSWIM1Zinc finger SWIM-type containing 1. (485 aa)
WFDC10AWAP four-disulfide core domain 10A. (79 aa)
WFDC8WAP four-disulfide core domain 8. (241 aa)
EPPINEppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. (133 aa)
WFDC6WAP four-disulfide core domain 6. (86 aa)
WFDC2WAP four-disulfide core domain protein 2; Broad range protease inhibitor. (124 aa)
SEMG2Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. (582 aa)
SEMG1Seminal basic protein; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. (462 aa)
WFDC12WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor. (111 aa)
WFDC5WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. (123 aa)
ZSWIM9Uncharacterized protein ZSWIM9; Zinc finger SWIM-type containing 9. (920 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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