STRINGSTRING
PI3 PI3 SPINT4 SPINT4 WFDC13 WFDC13 WFDC9 WFDC9 WFDC10A WFDC10A WFDC8 WFDC8 EPPIN EPPIN WFDC6 WFDC6 SEMG2 SEMG2 SEMG1 SEMG1 WFDC12 WFDC12 WFDC5 WFDC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PI3Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1). (117 aa)
SPINT4Serine peptidase inhibitor, Kunitz type 4. (99 aa)
WFDC13WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor. (93 aa)
WFDC9Protein WFDC9; WAP four-disulfide core domain 9. (89 aa)
WFDC10AWAP four-disulfide core domain 10A. (79 aa)
WFDC8WAP four-disulfide core domain 8. (241 aa)
EPPINEppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. (133 aa)
WFDC6WAP four-disulfide core domain 6. (86 aa)
SEMG2Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. (582 aa)
SEMG1Seminal basic protein; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. (462 aa)
WFDC12WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor. (111 aa)
WFDC5WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. (123 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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